BACKGROUND The association between the Vitamin D Receptor (VDR) gene polymorphism and the risk of Multiple sclerosis (MS) has been evaluated in several researches. However, the findings were inconsistent and inconclusive. Therefore, we set out a meta-analysis of all eligible published case-control studies to obtain an exact evaluation of the association between VDR gene polymorphisms and MS. METHOD All relevant studies reporting the association between the VDR gene FokI (rs2228570), or/and TaqI (rs731236) or/and BsmI (rs1544410) or/and ApaI (rs7975232) polymorphisms and susceptibility to MS published up to May, 2019 were identified by comprehensive systematic search in the electronic database of web of science, Scopus, and PubMed. After that, the strength of association between VDR gene polymorphisms and susceptibility to MS was evaluated by odds ratio (OR) and 95% confidence interval (CI). RESULTS A total of 30 case-control studies were included in the meta-analysis. The overall results suggested a significant association between TaqI polymorphism and MS risk under heterozygote genetic model (OR = 1.27, 95%CI = 1.01-1.59, random effect). Moreover, the pooled results of subgroup analysis declined presence of significant association under all defined genetic model. In subgroup analysis, BsmI polymorphisms was associated with increased risk of MS under recessive model in Asian populations. On the other hand, ApaI polymorphism was associated with decreased risk of MS under recessive and aa vs. AA model in Asian populations. CONCLUSION This meta-analysis suggested a significant association between TaqI polymorphism and MS susceptibility. Furthermore, BsmI polymorphism was associated with increased risk of MS in Asian populations. In contrast, ApaI polymorphism was associated with decreased risk of MS in Asian populations. Future large-scale studies on gene-environment and gene-gene interactions are required to estimate risk factors and assist early diagnosis of patients at high risk for MS.

中文翻译：

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维生素D受体（VDR）多态性与多发性硬化症（MS）风险之间的关联：最新的荟萃分析。

背景技术在多项研究中，已经评估了维生素D受体（VDR）基因多态性与多发性硬化症（MS）风险之间的关联。但是，调查结果不一致且无定论。因此，我们对所有符合条件的已发表病例对照研究进行了荟萃分析，以准确评估VDR基因多态性与MS之间的关联。方法鉴定了截至2019年5月发布的报告VDR基因FokI（rs2228570）或/和TaqI（rs731236）或/和BsmI（rs1544410）或/和ApaI（rs7975232）多态性与MS易感性之间关联的所有相关研究通过对科学网络，Scopus和PubMed的电子数据库进行全面的系统搜索。在那之后，通过比值比（OR）和95％置信区间（CI）评估VDR基因多态性与MS易感性之间的关联强度。结果荟萃分析共纳入30个病例对照研究。总体结果表明，在杂合子遗传模型下，TaqI多态性与MS风险之间存在显着关联（OR = 1.27，95％CI = 1.01-1.59，随机效应）。此外，在所有定义的遗传模型下，亚组分析的汇总结果均显示不存在显着关联。在亚组分析中，在亚洲人群中，BsmI多态性与隐性模型下MS风险增加相关。另一方面，在亚洲人群中，在隐性和aa vs.AA模式下，ApaI多态性与MS风险降低相关。结论这项荟萃分析表明TaqI多态性与MS易感性之间存在显着关联。此外，BsmI多态性与亚洲人群MS风险增加有关。相反，ApaI多态性与亚洲人群MS风险降低有关。需要对基因环境和基因-基因相互作用进行大规模的研究，以估计风险因素并协助早期诊断MS高危患者。