Anthelmintics in the future: current trends in the discovery and development of new drugs against gastrointestinal nematodes.,Drug Discovery Today

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Anthelmintics in the future: current trends in the discovery and development of new drugs against gastrointestinal nematodes.
Drug Discovery Today ( IF 6.5 ) Pub Date : 2019-12-26 , DOI: 10.1016/j.drudis.2019.12.007
Markéta Zajíčková ₁ , Linh Thuy Nguyen ₁ , Lenka Skálová ₁ , Lucie Raisová Stuchlíková ₁ , Petra Matoušková ₁

Affiliation

The control of gastrointestinal nematodes (GINs), the most abundant and serious parasites of livestock, has become difficult because of the limited number of available drugs and fast development of drug resistance. Thus, considerable efforts have been devoted to developing new anthelmintics that are efficient against nematodes, especially resistant species. Here, we summarize the most recent results using various approaches: target-based or high-throughput screening (HTS) of compound libraries; the synthesis of new derivatives or new combinations of current anthelmintics; the repurposing of drugs currently approved for other indications; and lastly, the identification of active plant products. We also evaluate the advantages and disadvantages of each of these approaches.

中文翻译：

未来的驱虫药：针对胃肠道线虫的新药发现和开发的当前趋势。

胃肠道线虫（GINs）是牲畜中最丰富，最严重的寄生虫，由于可用药物数量有限且耐药性迅速发展，因此已变得难以控制。因此，已经投入了相当大的努力来开发对线虫特别是抗性物种有效的新型驱虫药。在这里，我们使用各种方法总结了最新的结果：基于目标的化合物库或高通量筛选（HTS）；新的衍生物或当前驱虫药的新组合的合成；重新利用目前已批准用于其他适应症的药物；最后，确定活性植物产品。我们还评估了每种方法的优缺点。

更新日期：2019-12-27

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