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A strong CD8+ T cell-stimulating supramolecular hydrogel.
Nanoscale ( IF 5.8 ) Pub Date : 2020-01-08 , DOI: 10.1039/c9nr08916k
Xinxin Li 1 , Youzhi Wang , Siwan Wang , Chunhui Liang , Guojuan Pu , Yaoxia Chen , Ling Wang , Huae Xu , Yang Shi , Zhimou Yang
Affiliation  

The development of molecules with immune stimulatory properties is crucial for cancer immunotherapy. In this work, we combined two peptide-based molecules, tuftsin (TKPR) and Nap-GDFDFDY, to develop a novel self-assembling molecule Nap-GDFDFDYTKPR (Comp.3), which has strong CD8+ T cell stimulatory properties. Comp.3 could self-assemble into nanofibers and hydrogels, which significantly improved the stability of tuftsin against enzyme digestion. The nanofibers of Comp.3 enhanced the phagocytic activity of macrophages, promoted the maturation of DCs, and stimulated the expression of cytokines. In addition, it demonstrated an excellent anti-tumor efficacy in vivo by eliciting a strong CD8+ T immune response. Taken together, our observations revealed a powerful immune stimulating nanomaterial that is a promising compound for cancer immunotherapy.

中文翻译:

强烈的CD8 + T细胞刺激性超分子水凝胶。

具有免疫刺激特性的分子的发展对于癌症免疫治疗至关重要。在这项工作中,我们结合了两个基于肽的分子,簇夫星蛋白(TKPR)和Nap-GDFDFDY,开发出一种新型的自组装分子Nap-GDFDFDYTKTKPR(Comp.3),它具有很强的CD8 + T细胞刺激特性。Comp.3可以自组装成纳米纤维和水凝胶,从而显着提高了簇蛋白抗酶消化的稳定性。Comp.3的纳米纤维增强了巨噬细胞的吞噬活性,促进了DC的成熟,并刺激了细胞因子的表达。此外,它通过引发强烈的CD8 + T免疫反应,在体内表现出出色的抗肿瘤功效。综上所述,我们的观察结果揭示了一种强大的免疫刺激纳米材料,它是用于癌症免疫疗法的有前途的化合物。
更新日期:2020-01-08
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