BACKGROUND Although sarcopenia and frailty are important diseases in geriatrics, few studies have investigated the association between the two diseases. Thus, this study aimed to examine the relationship between two components of sarcopenia (muscle mass and muscle function) and frailty. METHODS In total, 997 Korean older adults (456 men and 541 women) were included in this cross-sectional observational study. We used a polynomial linear regression analysis to obtain standardized sex, age, and height-adjusted appendicular skeletal muscle mass (zASM), as well as to standardized sex, age, and height-adjusted grip strength (zGS). We then performed a causal mediation analysis to confirm the relationship between zASM and frailty. RESULTS In both men and women, zGS mediated the relationship between zASM and frailty (average causal mediation effect in men: -0.096 {-0.159 to -0.050}; in women: -0.053 {-0.098 to -0.010}). For every one-point increase in zGS score, the relative risk of a one-point increase in frailty was reduced by 21% in men (e-0.238 = 0.788) and by 11% in women (e-0.113 = 0.893). CONCLUSIONS In this study on Korean older adults, muscle mass did not have a direct effect on frailty but had an indirect effect through altered muscle function.

中文翻译：

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握力调节了肌肉质量与虚弱之间的关系。

背景技术尽管少肌症和衰弱是老年病中的重要疾病，但很少有研究调查这两种疾病之间的关联。因此，本研究旨在检查肌肉减少症的两个组成部分（肌肉质量和肌肉功能）与虚弱之间的关系。方法这项横断面观察研究总共包括997名韩国老年人（456名男性和541名女性）。我们使用多项式线性回归分析来获得标准化的性别，年龄和身高调整后的阑尾骨骼肌质量（zASM），以及标准化的性别，年龄和身高调整后的握力（zGS）。然后，我们进行了因果中介分析，以确认zASM与脆弱之间的关系。结果无论是男性还是女性，zGS介导了zASM与体弱之间的关系（男性的平均因果调节作用：-0.096 {-0.159至-0.050}；女性：-0.053 {-0.098至-0.010}）。zGS分数每提高1分，男性的脆弱性每升高1分的相对风险就降低了21％（e-0.238 = 0.788），而女性则降低了11％（e-0.113 = 0.893）。结论在这项针对韩国老年人的研究中，肌肉质量对衰弱没有直接影响，但通过改变肌肉功能具有间接影响。