Male Syrian hamsters (Mesocricetus auratus) administered anabolic/androgenic steroids during adolescent development display increased aggression and decreased anxious behavior during the adolescent exposure period. Upon withdrawal from anabolic/androgenic steroids, this neurobehavioral relationship shifts and hamsters exhibit decreased aggression and increased anxious behavior. This study investigated the hypothesis that alterations in anterior hypothalamic signaling through serotonin type-3 receptors modulate the behavioral shift between adolescent anabolic/androgenic steroid-induced aggressive and anxious behaviors during the withdrawal period. To test this, hamsters were administered anabolic/androgenic steroids during adolescence then withdrawn from drug exposure for 21 days and tested for aggressive and anxious behaviors following direct pharmacological manipulation of serotonin type-3 receptor signaling within the latero-anterior hypothalamus. Blockade of latero-anterior hypothalamic serotonin type-3 receptors both increased aggression and decreased anxious behavior in steroid-treated hamsters, effectively reversing the pattern of behavioral responding normally observed during anabolic/androgenic steroid withdrawal. These findings suggest that the state of serotonin neural signaling within the latero-anterior hypothalamus plays an important role in behavioral shifting between aggressive and anxious behaviors following adolescent exposure to anabolic/androgenic steroids.

中文翻译：

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从青少年合成代谢类固醇暴露中撤退期间，血清素3型受体差异性调节焦虑和攻击性。

在青春期发育期间服用合成代谢/雄激素类固醇的雄性叙利亚仓鼠（Mesocricetus auratus）在青春期暴露期间表现出增加的攻击性和焦虑行为。从合成代谢/雄激素类固醇撤出后，这种神经行为关系发生变化，仓鼠表现出降低的攻击性和焦虑行为。这项研究调查了以下假设，即通过下丘脑3型受体的下丘脑前部信号传导的改变会在停药期调节青少年合成代谢/雄激素类固醇诱导的攻击性行为和焦虑行为之间的行为转变。为了测试这个 仓鼠在青春期期间给予合成代谢/雄激素类固醇，然后从暴露于药物中撤出21天，并在药理作用下在下丘脑-前下丘脑内直接进行药理操作后测试其侵略性和焦虑行为。在类固醇治疗的仓鼠中，对后下丘脑3型血清素3型受体的阻断既增加了攻击性又减少了其焦虑行为，从而有效地逆转了在合成代谢/雄激素类固醇戒断期间通常观察到的行为反应模式。这些发现表明，青少年暴露于合成代谢/雄激素类固醇后，下丘脑-前下丘脑内5-羟色胺神经信号的状态在攻击行为与焦虑行为之间的行为转换中起着重要作用。