Ionic liquids are a diverse range of charged chemicals with low volatility and often liquids at ambient temperatures. This characteristic has in part lead to them being considered environmentally-friendly replacements for existing volatile solvents. However, methylimidazolium ionic liquids are slow to break down in the environment and a recent study at Newcastle detected 1 octyl 3 methylimidazolium (M8OI) - an 8 carbon variant methylimidazolium ionic liquid - in soils in close proximity to a landfill site. The current M8OI toxicity database in cultured mammalian cells, in experimental animal studies and in model indicators of environmental impact are reviewed. Selected analytical data from the Newcastle study suggest the soils in close proximity to the landfill site, an urban soil lacking overt contamination, had variable levels of M8OI. The potential for M8OI - or a structurally related ionic liquid - to trigger primary biliary cholangitis (PBC), an autoimmune liver disease thought to be triggered by an unknown agent(s) in the environment, is reviewed.

中文翻译：

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甲基咪唑鎓离子液体的毒性，重点是 M8OI 和肝脏影响。


离子液体是多种带电化学物质，挥发性低，在环境温度下通常为液体。这一特性在一定程度上导致它们被认为是现有挥发性溶剂的环保替代品。然而，甲基咪唑鎓离子液体在环境中分解缓慢，纽卡斯尔最近的一项研究在垃圾填埋场附近的土壤中检测到 1 辛基 3 甲基咪唑鎓 (M8OI)——一种 8 碳变体甲基咪唑鎓离子液体。回顾了当前 M8OI 在培养哺乳动物细胞、实验动物研究和环境影响模型指标中的毒性数据库。纽卡斯尔研究的部分分析数据表明，靠近垃圾填埋场的土壤（没有明显污染的城市土壤）的 M8OI 水平存在差异。综述了 M8OI（或结构相关的离子液体）引发原发性胆汁性胆管炎 (PBC) 的可能性，PBC 是一种被认为由环境中未知物质引发的自身免疫性肝病。