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Immune Th17 lymphocytes play a critical role in the multiple beneficial properties of resveratrol.
Food and Chemical Toxicology ( IF 3.9 ) Pub Date : 2019-12-26 , DOI: 10.1016/j.fct.2019.111091
Dominique Delmas 1 , Emeric Limagne 2 , François Ghiringhelli 1 , Virginie Aires 3
Affiliation  

Modulation of the inflammatory response is one of the major issues of the 21st century due to its importance in the occurrence of various pathologies (cancer, autoimmune diseases, degenerative diseases) and their progression over time. Whether acute or chronic, the inflammatory response is directly related to the immune response through different subtypes of T lymphocytes. In addition, among the compounds capable of modulating the cells of the immune system, resveratrol, a polyphenol with pleiotropic biological properties, seems to be a good candidate. Indeed, resveratrol is able to alter the immune response by modulating the process of lymphocyte differentiation and subsequently diminishing the inflammatory-associated response. More specifically, thanks to its ability to act as a sirtuin-1 agonist, it can deacetylate the transcription factor STAT3 and alter nuclear factors essential to the process of lymphocyte differentiation. We present and discuss these different aspects in relation to various pathologies and how the alteration of the ratios between the different lymphocyte subtypes by resveratrol is an important element to take into account when studying its anti-inflammatory and immunomodulatory properties.

中文翻译:

免疫Th17淋巴细胞在白藜芦醇的多种有益特性中起关键作用。

炎症反应的调节是21世纪的主要问题之一,因为它在各种病理(癌症,自身免疫性疾病,退化性疾病)的发生及其随着时间的发展中具有重要意义。不论是急性的还是慢性的,炎症反应都通过不同的T淋巴细胞亚型与免疫反应直接相关。此外,在能够调节免疫系统细胞的化合物中,白藜芦醇是一种具有多效性生物学特性的多酚,似乎是一个不错的选择。实际上,白藜芦醇能够通过调节淋巴细胞分化过程并随后减少与炎症相关的应答来改变免疫应答。更具体地说,由于它具有充当sirtuin-1激动剂的能力,它可以使转录因子STAT3脱乙酰,并改变淋巴细胞分化过程中必不可少的核因子。我们提出并讨论了与各种病理学相关的这些不同方面,以及在研究白藜芦醇的抗炎和免疫调节特性时如何考虑白藜芦醇改变不同淋巴细胞亚型之间的比率是一个重要因素。
更新日期:2019-12-27
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