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Epidemiology and Clinical Outcomes of Hospitalizations for Acute Respiratory or Febrile Illness and Laboratory-Confirmed Influenza Among Pregnant Women During Six Influenza Seasons, 2010-2016.
The Journal of Infectious Diseases ( IF 6.4 ) Pub Date : 2020-04-27 , DOI: 10.1093/infdis/jiz670
Fatimah S Dawood 1 , Shikha Garg 1 , Rebecca V Fink 2 , Margaret L Russell 3 , Annette K Regan 4 , Mark A Katz 5, 6, 7 , Stephanie Booth 3 , Hannah Chung 8 , Nicola P Klein 9 , Jeffrey C Kwong 8, 10, 11 , Avram Levy 12 , Allison Naleway 13 , Dan Riesel 5 , Mark G Thompson 1 , Brandy E Wyant 2 , Deshayne B Fell 8, 14, 15
Affiliation  

BACKGROUND Pregnant women are at increased risk of seasonal influenza hospitalizations, but data about the epidemiology of severe influenza among pregnant women remain largely limited to pandemics. METHODS To describe the epidemiology of hospitalizations for acute respiratory infection or febrile illness (ARFI) and influenza-associated ARFI among pregnant women, administrative and electronic health record data were analyzed from retrospective cohorts of pregnant women hospitalized with ARFI who had testing for influenza viruses by reverse-transcription polymerase chain reaction (RT-PCR) in Australia, Canada, Israel, and the United States during 2010-2016. RESULTS Of 18 048 ARFI-coded hospitalizations, 1064 (6%) included RT-PCR testing for influenza viruses, 614 (58%) of which were influenza positive. Of 614 influenza-positive ARFI hospitalizations, 35% were in women with low socioeconomic status, 20% with underlying conditions, and 67% in their third trimesters. The median length of influenza-positive hospitalizations was 2 days (interquartile range, 1-4), 18% (95% confidence interval [CI], 15%-21%) resulted in delivery, 10% (95% CI, 8%-12%) included a pneumonia diagnosis, 5% (95% CI, 3%-6%) required intensive care, 2% (95% CI, 1%-3%) included a sepsis diagnosis, and <1% (95% CI, 0%-1%) resulted in respiratory failure. CONCLUSIONS Our findings characterize seasonal influenza hospitalizations among pregnant women and can inform assessments of the public health and economic impact of seasonal influenza on pregnant women.

中文翻译:

2010-2016 年六个流感季节孕妇因急性呼吸系统或发热性疾病以及实验室确诊流感住院的流行病学和临床结果。

背景技术孕妇患季节性流感住院的风险增加,但有关孕妇严重流感流行病学的数据仍然主要限于大流行。方法 为了描述孕妇中因急性呼吸道感染或发热性疾病 (ARFI) 和流感相关 ARFI 住院的流行病学,对因 ARFI 住院且接受过流感病毒检测的孕妇的回顾性队列分析了行政和电子健康记录数据2010-2016 年澳大利亚、加拿大、以色列和美国的逆转录聚合酶链反应 (RT-PCR)。结果 在 18 048 例 ARFI 编码的住院治疗中,1064 例 (6%) 进行了流感病毒 RT-PCR 检测,其中 614 例 (58%) 呈流感阳性。在 614 例流感阳性 ARFI 住院患者中,35% 为社会经济地位较低的女性,20% 有基础疾病,67% 为妊娠晚期女性。流感阳性住院时间中位数为 2 天(四分位数范围,1-4),18%(95% 置信区间 [CI],15%-21%)最终分娩,10%(95% CI,8%) -12%)包括肺炎诊断,5%(95% CI,3%-6%)需要重症监护,2%(95% CI,1%-3%)包括败血症诊断,<1%(95 % CI,0%-1%)导致呼吸衰竭。结论 我们的研究结果描述了孕妇季节性流感住院的特征,可以为评估季节性流感对孕妇的公共卫生和经济影响提供信息。
更新日期:2019-12-27
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