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The Arabidopsis Receptor Kinase IRK Is Polarized and Represses Specific Cell Divisions in Roots.
Developmental Cell ( IF 10.7 ) Pub Date : 2019-12-26 , DOI: 10.1016/j.devcel.2019.12.001
Roya Campos 1 , Jason Goff 1 , Cecilia Rodriguez-Furlan 1 , Jaimie M Van Norman 1
Affiliation  

Development of multicellular organisms requires coordination of cell division and differentiation across tissues. In plants, directional signaling, and implicitly cell polarity, is proposed to participate in this coordination; however, mechanistic links between intercellular signaling, cell polarity, and cellular organization remain unclear. Here, we investigate the localization and function of INFLORESCENCE AND ROOT APICES RECEPTOR KINASE (IRK) in root development. We find that IRK-GFP localizes to the outer plasma membrane domain in endodermal cells but localizes to different domains in other cell types. Our results suggest that IRK localization is informed locally by adjacent cell types. irk mutants have excess cell divisions in the ground tissue stem cells and endodermis, indicating IRK functions to maintain tissue organization through inhibition of specific cell divisions. We predict that IRK perceives a directional cue that negatively regulates these cell divisions, thus linking intercellular signaling and cell polarity with the control of oriented cell divisions during development.

中文翻译:

拟南芥受体激酶IRK被极化并抑制根中的特定细胞分裂。

多细胞生物的发展需要协调组织间的细胞分裂和分化。在植物中,定向信号和隐含的细胞极性被提议参与这种协调。然而,细胞间信号传导,细胞极性和细胞组织之间的机制联系仍不清楚。在这里,我们调查了根发育过程中INFLORESCENCE和ROOT API受体激酶(IRK)的定位和功能。我们发现,IRK-GFP定位于内胚层细胞中的外质膜结构域,但定位于其他细胞类型中的不同结构域。我们的结果表明,IRK本地化是由相邻细胞类型本地告知的。irk突变体在地面组织干细胞和内胚层中有多余的细胞分裂,提示IRK的功能是通过抑制特定的细胞分裂来维持组织的组织。我们预测,IRK会感知到一个负向调节这些细胞分裂的方向性提示,从而将细胞间信号传导和细胞极性与发育过程中定向细胞分裂的控制联系起来。
更新日期:2019-12-27
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