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Magnetic resonance energy transfer for in vivo glutathione susceptibility weighted imaging.
Biomaterials ( IF 12.8 ) Pub Date : 2019-12-26 , DOI: 10.1016/j.biomaterials.2019.119703 Kun Wang 1 , Huilin Zhang 1 , Aijun Shen 2 , Peiran Zhao 1 , Xianfu Meng 1 , Xiaoyan Chen 1 , Yang Liu 1 , Yanyan Liu 1 , Teng Gong 1 , Wanlu Wu 3 , Xiangming Fang 3 , Peijun Wang 2 , Wenbo Bu 1
Biomaterials ( IF 12.8 ) Pub Date : 2019-12-26 , DOI: 10.1016/j.biomaterials.2019.119703 Kun Wang 1 , Huilin Zhang 1 , Aijun Shen 2 , Peiran Zhao 1 , Xianfu Meng 1 , Xiaoyan Chen 1 , Yang Liu 1 , Yanyan Liu 1 , Teng Gong 1 , Wanlu Wu 3 , Xiangming Fang 3 , Peijun Wang 2 , Wenbo Bu 1
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Glutathione (GSH) plays a vital role in maintaining biological redox homeostasis. Accordingly, accurate imaging of glutathione in vivo is of great significance. Herein, we propose a magnetic resonance energy transfer (MRET) strategy based on a distance-dependent magnetic exchange coupling effect (MECE), which can realize GSH detection within tumors in vivo by susceptibility weighted imaging (SWI). Fe3O4 nanoparticles (NPs) and CoFe2O4 NPs linked with cystamine (Fe3O4-S-S-CoFe2O4) have been successfully designed as SWI nanoprobes. After the disulfide bonds are broken by excess GSH in the tumor, the increase in the distance between Fe3O4 NPs and CoFe2O4 NPs will induce a decrease of MECE and magnetic susceptibility. As a result, the changes in the SWI signals are used for tumor GSH detection in vivo. Experimental results in vitro and in vivo demonstrate that the Fe3O4-S-S-CoFe2O4 SWI nanoprobe can sensitively detect concentrations of GSH in tumors. Hence, this strategy not only improves the sensitivity of the GSH response in SWI but also provides a powerful basis for the design of other responsive functional MRI nanoprobes.
中文翻译：
磁共振能量转移用于体内谷胱甘肽敏感性加权成像。
谷胱甘肽（GSH）在维持生物氧化还原稳态方面起着至关重要的作用。因此，体内谷胱甘肽的精确成像具有重要意义。本文中，我们提出了一种基于距离依赖的磁交换耦合效应（MECE）的磁共振能量转移（MRET）策略，该策略可通过磁化加权成像（SWI）实现体内肿瘤内的GSH检测。Fe3O4纳米颗粒（NPs）和与胱胺连接的CoFe2O4 NPs（Fe3O4-SS-CoFe2O4）已成功设计为SWI纳米探针。在肿瘤中过量的GSH破坏了二硫键后，Fe3O4 NPs和CoFe2O4 NPs之间距离的增加将引起MECE和磁化率的降低。结果，SWI信号的变化被用于体内肿瘤GSH检测。体外和体内实验结果表明，Fe3O4-SS-CoFe2O4 SWI纳米探针可以灵敏地检测肿瘤中GSH的浓度。因此，该策略不仅提高了SWI中GSH反应的敏感性，而且为设计其他响应性功能性MRI纳米探针提供了有力的基础。
更新日期：2019-12-27
中文翻译：
磁共振能量转移用于体内谷胱甘肽敏感性加权成像。
谷胱甘肽（GSH）在维持生物氧化还原稳态方面起着至关重要的作用。因此，体内谷胱甘肽的精确成像具有重要意义。本文中，我们提出了一种基于距离依赖的磁交换耦合效应（MECE）的磁共振能量转移（MRET）策略，该策略可通过磁化加权成像（SWI）实现体内肿瘤内的GSH检测。Fe3O4纳米颗粒（NPs）和与胱胺连接的CoFe2O4 NPs（Fe3O4-SS-CoFe2O4）已成功设计为SWI纳米探针。在肿瘤中过量的GSH破坏了二硫键后，Fe3O4 NPs和CoFe2O4 NPs之间距离的增加将引起MECE和磁化率的降低。结果，SWI信号的变化被用于体内肿瘤GSH检测。体外和体内实验结果表明，Fe3O4-SS-CoFe2O4 SWI纳米探针可以灵敏地检测肿瘤中GSH的浓度。因此，该策略不仅提高了SWI中GSH反应的敏感性，而且为设计其他响应性功能性MRI纳米探针提供了有力的基础。
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