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Segmental analysis of antidepressant and antipsychotic drugs in the hair of schizophrenic patients.
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-01-21 , DOI: 10.1002/dta.2754
Xin Wang 1 , Yue Zhuo 1, 2 , Xiaowei Tang 3 , Huosheng Qiang 1 , Wei Liu 1 , Hejian Wu 1 , Ping Xiang 1 , Gengli Duan 4 , Min Shen 1
Affiliation  

Hair analysis is useful for documenting long‐term exposure to drugs. The potential of hair analysis for therapeutic drug monitoring within the forensic field has been studied, but reference values for some antidepressants and antipsychotics in the hair of individuals undergoing chronic therapy are still lacking. In the present study, a method was developed and validated for the determination of 23 analytes, including antidepressants, antipsychotics, and related metabolites, in human hair by liquid chromatography–tandem mass spectrometry (LC–MS/MS). Hair samples (10 mg) were extracted with a 25:25:50 (v/v/v) mixture of methanol/acetonitrile/2 mM ammonium formate (8% acetonitrile, pH 5.3) utilizing cryogenic grinding. The present method demonstrated sufficient selectivity, robustness, and accuracy. Sixteen analytes in hair were reported in 46 psychiatric patients receiving fixed drug dosages. To the best of our knowledge, the hair concentrations of perphenazine and norolanzapine, as well as the concentrations of amisulpride, aripiprazole and its metabolite dehydroaripiprazole, olanzapine, and sulpiride, in hair from individuals receiving fixed dosages is reported for the first time. A significant relationship between the administered dose and the concentration in the proximal hair segment was found only for clozapine, norclozapine, and chlorpromazine. The results confirmed that the idea of using hair concentrations to monitor a daily dose is inapplicable.

中文翻译:

精神分裂症患者头发中抗抑郁药和抗精神病药的细分分析。

头发分析可用于记录长期接触药物的情况。已经研究了在法医学领域中进行头发分析以监测治疗药物的潜力,但仍缺乏接受慢性治疗的人头发中某些抗抑郁药和抗精神病药的参考值。在本研究中,通过液相色谱-串联质谱法(LC-MS / MS),开发并验证了一种测定人发中23种分析物的方法,包括抗抑郁药,抗精神病药和相关代谢物。用甲醇/乙腈/ 2 mM甲酸铵(8%乙腈,pH 5.3)的25:25:50(v / v / v)混合物提取样品(10 mg),并进行低温研磨。本方法证明了足够的选择性,鲁棒性和准确性。据报道,接受固定药物剂量的46位精神病患者的头发中有16种分析物。据我们所知,首次报告了接受固定剂量的人头发中的奋乃静和去甲去氮平的头发浓度以及氨磺必利,阿立哌唑及其代谢产物脱氢阿立哌唑,奥氮平和舒必利的浓度。仅在氯氮平,去甲氯氮平和氯丙嗪中发现给药剂量和近端毛发段浓度之间的显着关系。结果证实了使用头发浓度监测每日剂量的想法是不适用的。首次报告了接受固定剂量的人的头发中的阿立哌唑及其代谢产物脱氢阿立哌唑,奥氮平和舒必利。仅对于氯氮平,去甲氯氮平和氯丙嗪,发现给药剂量与近端毛发段浓度之间存在显着关系。结果证实了使用头发浓度监测每日剂量的想法是不适用的。首次报告了接受固定剂量的人的头发中的阿立哌唑及其代谢产物脱氢阿立哌唑,奥氮平和舒必利。仅对于氯氮平,去甲氯氮平和氯丙嗪,发现给药剂量与近端毛发段浓度之间存在显着关系。结果证实了使用头发浓度监测每日剂量的想法是不适用的。
更新日期:2020-01-21
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