Obesity and type 2 diabetes have been shown to be associated with chronic inflammation. Despite extensive evidence for inflammatory mediators in the obese patients and multiple clinical trials, the outcome has been disappointing. In murine models recruitment of immune cells during inflammation has been shown to contribute to the chronic inflammation. Clearcut evidence for the differential expression of chemokines that mediate this recruitment is not available. In this short review we discuss the observations on CCL2 and CCL5 in human obesity.

中文翻译：

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人类肥胖的趋化因子

肥胖和 2 型糖尿病已被证明与慢性炎症有关。尽管有大量证据表明肥胖患者存在炎症介质，并且进行了多项临床试验，但结果令人失望。在小鼠模型中，炎症期间免疫细胞的募集已被证明有助于慢性炎症。没有关于介导这种招募的趋化因子差异表达的明确证据。在这篇简短的评论中，我们讨论了人类肥胖症中 CCL2 和 CCL5 的观察结果。