Despite the importance of magnetic properties of biological samples for biomagnetism and related fields, the exact magnetic susceptibilities of most biological samples in their physiological conditions are still unknown. Here we used superconducting quantum interferometer device to detect the magnetic properties of nonfixed, nondehydrated live cell and cellular fractions at a physiological temperature of 37°C (310 K). It is obvious that there are paramagnetic components within human nasopharyngeal carcinoma CNE-2Z cells. More importantly, the magnetic properties of the cytoplasm and nucleus are different. Although within a single cell, the magnetic susceptibility difference between cellular fractions (nucleus and cytoplasm) could only cause ∼41–130 pN forces to the nucleus by gradient ultrahigh magnetic fields of 13.1–23.5 T (92–160 T/m), these forces are enough to cause a relative position shift of the nucleus within the cell. This not only demonstrates the importance of magnetic susceptibility in the biological effects of magnetic field but also illustrates the potential application of high magnetic fields in biomedicine.

中文翻译：

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梯度超高磁场中磁化率差异引起的核定位

尽管生物样品的磁性对生物磁性和相关领域很重要，但大多数生物样品在其生理条件下的确切磁化率仍然未知。在这里，我们使用超导量子干涉仪设备在 37°C (310 K) 的生理温度下检测未固定、未脱水的活细胞和细胞组分的磁性。很明显，人鼻咽癌CNE-2Z细胞内存在顺磁性成分。更重要的是，细胞质和细胞核的磁性不同。尽管在单个细胞内，细胞部分（细胞核和细胞质）之间的磁化率差异只能通过 13.1-23.5 T (92-160 T/m) 的梯度超高磁场对细胞核产生 ~41-130 pN 力，这些力足以引起细胞内细胞核的相对位置偏移。这不仅证明了磁化率在磁场生物效应中的重要性，也说明了强磁场在生物医学中的潜在应用。