This study was conducted to evaluate the impact of varying scleral material properties on the biomechanical response of the cornea under air-puff induced deformation. Twenty pairs of human donor eyes were obtained for this study. One eye from each pair had its sclera stiffened using 4% glutaraldehyde, while the fellow eye served as control for uniaxial strip testing. The whole globes were mounted in a rigid holder and intraocular pressure (IOP) was set using a saline column. Dynamic corneal response parameters were measured before and after scleral stiffening using the CorVis ST, a dynamic Scheimpflug analyzer. IOP was set to 10, 20, 30, and 40 mmHg, with at least 3 examinations performed at each pressure step. Uniaxial tensile testing data were fit to a neo-Hookean model to estimate the Young's modulus of treated and untreated sclera. Scleral Young's modulus was found to be significantly correlated with several response parameters, including Highest Concavity Deformation Amplitude, Peak Distance, Highest Concavity Radius, and Stiffness Parameter-Highest Concavity (SP-HC). There were significant increases in SP-HC after scleral stiffening at multiple levels of IOP, while no significant difference was observed in the corneal Stiffness Parameter - Applanation 1 (SP-A1) at any level of IOP. Scleral mechanical properties significantly influenced the corneal deformation response to an air-puff. The stiffer the sclera, the greater the constraining effect on corneal deformation resulting in lower displaced amplitude. This may have important clinical implications and suggests that both corneal and scleral material properties contribute to the observed corneal response in air-puff induced deformation.

中文翻译：

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巩膜对气喘引起的动态角膜反应的生物力学作用在人供体眼睛中引起变形。

进行了这项研究，以评估巩膜材料特性的变化对气胀引起的变形下角膜生物力学响应的影响。这项研究获得了二十对人类供体眼睛。每对中的一只眼睛使用4％戊二醛使巩膜变硬，而另一只眼睛则用作单轴剥离测试的对照。将整个球体安装在刚性支架中，并使用盐水柱设置眼内压（IOP）。动态巩膜硬化前后，使用动态的Scheimpflug分析仪CorVis ST测量角膜动态响应参数。IOP设置为10、20、30和40 mmHg，每个压力步骤至少进行3次检查。单轴拉伸试验数据适合于新霍克模型，以估计治疗和未治疗巩膜的杨氏模量。发现巩膜杨氏模量与几个响应参数显着相关，包括最高凹形变形幅度，峰距，最高凹形半径和刚度参数最高凹形（SP-HC）。在多个IOP水平下巩膜硬化后，SP-HC显着增加，而在任何IOP水平下，角膜刚度参数-压平1（SP-A1）均未观察到显着差异。巩膜的机械性能显着影响了对气穴的角膜变形反应。巩膜越硬，对角膜变形的约束作用越大，导致位移幅度越低。