Optimized Cytocompatibility and Antimicrobial Activity of Octacalcium Phosphate/ε-Polylysine Composite Coating Electrochemically Codeposited on Medical Titanium,ACS Applied Bio Materials

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Optimized Cytocompatibility and Antimicrobial Activity of Octacalcium Phosphate/ε-Polylysine Composite Coating Electrochemically Codeposited on Medical Titanium
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-01-08 , DOI: 10.1021/acsabm.9b00844
Jiejie Hu ₁ , Yanmei Zhang _{1,

2} , Lili Fan ₃ , Yun Yang ₄ , Ren Hu ₁ , Qiaoling Huang ₄ , Gang Rui ₅ , Changjian Lin _{1,

2,

4}

Affiliation

Preventing bacterial infection of bone implants is a major challenge for developing functional biomedical materials at present. With more significant emergence of drug-resistant bacteria, exploration of antimicrobial materials has become increasingly important and urgent. More and more researchers have devoted their work to the study of a kind of antimicrobial material for improving inhibition of drug-resistant bacteria, and other bioproperties as well. In this work, we first introduced ε-polylysine (ε-PL), which possessed a broad antibacterial spectrum and negligible cytotoxicity to the human body, into an octacalcium phosphate (OCP) coating on a titanium surface by electrochemical codeposition (ED). The measurements of the structure and composition of the OCP/ε-PL composite coating demonstrated that ε-PL had succeeded in combining with OCP. The bioactivity assessment of all samples indicated that the OCP/ε-PL composite film had owned good biological mineralization capability. In vitro, it also had better ability to promote cell proliferation and differentiation when the concentration of ε-PL was 10 mg/mL compared with other concentrations. In the meanwhile, the antibacterial test indicated that the ε-PL introduced to OCP was able to markedly improve the antibacterial property against both Gram-positive and Gram-negative bacteria.

中文翻译：

医用钛电化学共沉积磷酸八钙/ε-聚赖氨酸复合涂层的优化细胞相容性和抗菌活性

防止骨植入物的细菌感染是目前开发功能性生物医学材料的主要挑战。随着耐药菌的大量出现，抗菌材料的探索变得越来越重要和紧迫。越来越多的研究人员致力于研究一种抗菌材料，以提高对耐药细菌的抑制作用以及其他生物特性。在这项工作中，我们首先通过电化学共沉积（ED）将具有广泛抗菌谱和对人体细胞毒性可忽略不计的ε-聚赖氨酸（ε-PL）引入钛表面的磷酸八钙（OCP）涂层中。对OCP/ε-PL复合涂层的结构和成分的测量表明，ε-PL已经成功地与OCP结合。所有样品的生物活性评价表明，OCP/ε-PL复合膜具有良好的生物矿化能力。在体外，与其他浓度相比，当ε-PL浓度为10 mg/mL时，它也具有更好的促进细胞增殖和分化的能力。同时，抗菌试验表明，引入OCP的ε-PL能够显着提高对革兰氏阳性菌和革兰氏阴性菌的抗菌性能。

更新日期：2020-01-08

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