Determinants of physical, mental and social well-being: a longitudinal environment-wide association study.,International Journal of Epidemiology

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Determinants of physical, mental and social well-being: a longitudinal environment-wide association study.
International Journal of Epidemiology ( IF 6.4 ) Pub Date : 2019-12-23 , DOI: 10.1093/ije/dyz238
Michael Y Ni _{1,

2,

3} , Xiaoxin I Yao ₁ , Felix Cheung ₁ , Joseph T Wu ₁ , C Mary Schooling _{1,

4} , Herbert Pang ₁ , Gabriel M Leung ₁

Affiliation

BACKGROUND Although the World Health Organization (WHO) has defined health as a state of physical, mental and social well-being, public health strategies have primarily focused on one domain of well-being. We sought to systematically and simultaneously identify and validate associations of behavioural patterns, psychosocial factors, mental and physical health conditions, access to and utilization of health care and anthropometrics with physical, mental and social well-being. METHODS We conducted a longitudinal environment-wide association study (EWAS) with a training and testing set approach, accounting for multiple testing using a false discovery rate control. We used multivariate multilevel regression to examine the association of each exposure at wave 1 with the three outcomes at wave 2 in the Hong Kong FAMILY Cohort (n = 10 484). RESULTS Out of 194 exposures, we identified and validated 14, 5 and 5 exposures that were individually associated with physical, mental and social well-being, respectively. We discovered three factors, namely depressive symptoms, life satisfaction and happiness, that were simultaneously associated with the three domains that define health. CONCLUSIONS These associations, if verified to be causal, could become intervention targets to holistically improve population health. Our findings provide empirical support for placing mental health at the forefront of the public health agenda, and also support recent calls to use life satisfaction and happiness to guide public policy.

更新日期：2019-12-25

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