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Oral treatment with Lactobacillus reuteri attenuates depressive-like behaviors and serotonin metabolism alterations induced by chronic social defeat stress.
Journal of Psychiatric Research ( IF 3.7 ) Pub Date : 2019-12-24 , DOI: 10.1016/j.jpsychires.2019.12.013 Ruining Xie 1 , Pei Jiang 2 , Li Lin 1 , Jian Jiang 1 , Bin Yu 3 , Jingjing Rao 4 , Hui Liu 1 , Wei Wei 1 , Yi Qiao 1
Journal of Psychiatric Research ( IF 3.7 ) Pub Date : 2019-12-24 , DOI: 10.1016/j.jpsychires.2019.12.013 Ruining Xie 1 , Pei Jiang 2 , Li Lin 1 , Jian Jiang 1 , Bin Yu 3 , Jingjing Rao 4 , Hui Liu 1 , Wei Wei 1 , Yi Qiao 1
Affiliation
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BACKGROUND
Alterations in bidirectional gut-brain interactions are believed to be involved in the pathogenesis of neuropsychiatric diseases. Considering the putative connections among gut microbiota, neural function, and behavior, this study investigated the potential of microbe-induced gut-to-brain signaling to modulate the impact of stress on depressive-like behaviors and serotonin metabolism.
METHODS
Depression-susceptible mice induced by chronic social defeat stress received oral treatment of either Lactobacillus reuteri 3 (L. reuteri 3) or vehicle for 28 days, and alterations in behavior and serotonin metabolism were assessed. 16S rRNA sequencing and gas chromatograph were employed to analyze the gut microbiota community and short-chain fatty acids (SCFAs).
RESULTS
Treatment with L. reuteri 3 ameliorated depressive-like behaviors, suppressed the increase in the relative abundances of Clostridiales and Adlercreutzia, improved the decrease in abundances of Lactobacillus, Allobaculum, and Sutterella induced by stress, and significantly increased the proportion of Bifidobacterium. L. reuteri 3 reduced the acetate and total SCFAs levels in the depression group. Blood and colon 5-HT were decreased in depressive-like mice but were significantly ameliorated after L. reuteri 3 treatment. Moreover, L. reuteri 3 administration increased the expression of enzymes involved in serotonin biosynthesis but suppressed that of the enzymes involved in tryptophan metabolism along the kynurenine pathway in colon and prefrontal cortex.
CONCLUSIONS
Despite the complexity of the gut microbiota, exposure to a single microbial strain L. reuteri 3 can protect against depressive-like behaviors induced by chronic social defeat stress. The anti-depressive effects of L. reuteri 3 were associated with improved gut microbiota and serotonin metabolism.
中文翻译：
罗伊氏乳杆菌的口服治疗可减轻由慢性社交失败压力引起的抑郁样行为和5-羟色胺代谢改变。
背景技术双向肠脑相互作用的改变被认为与神经精神疾病的发病机理有关。考虑到肠道菌群，神经功能和行为之间的假定联系，本研究调查了微生物诱导的肠道到大脑信号传导调节压力对抑郁样行为和5-羟色胺代谢的影响的潜力。方法慢性社交衰竭应激诱发的抑郁易感小鼠接受罗伊氏乳杆菌3（L. reuteri 3）或媒介物的口服治疗28天，并评估其行为和血清素代谢的变化。16S rRNA测序和气相色谱仪用于分析肠道菌群和短链脂肪酸（SCFA）。结果罗伊氏乳杆菌3的治疗改善了抑郁样行为，抑制了梭状芽胞杆菌和adlercreutzia的相对丰度的增加，改善了由压力引起的乳酸杆菌，同种杆菌和Sutterella丰度的降低，并显着增加了双歧杆菌的比例。罗伊氏乳杆菌3降低了抑郁症组的乙酸盐和总SCFA水平。抑郁样小鼠的血液和5-HT含量降低，但在罗伊氏乳杆菌3处理后明显改善。此外，罗伊氏乳杆菌3的施用增加了与5-羟色胺生物合成有关的酶的表达，但抑制了沿结肠和前额叶皮质中的犬尿氨酸途径的色氨酸代谢所涉及的酶的表达。结论尽管肠道菌群很复杂，但暴露于单个微生物菌株L。罗伊特氏菌3可以预防由慢性社交失败压力引起的类似抑郁的行为。罗伊氏乳杆菌3的抗抑郁作用与肠道菌群和5-羟色胺代谢改善有关。
更新日期：2019-12-25
中文翻译：
罗伊氏乳杆菌的口服治疗可减轻由慢性社交失败压力引起的抑郁样行为和5-羟色胺代谢改变。
背景技术双向肠脑相互作用的改变被认为与神经精神疾病的发病机理有关。考虑到肠道菌群，神经功能和行为之间的假定联系，本研究调查了微生物诱导的肠道到大脑信号传导调节压力对抑郁样行为和5-羟色胺代谢的影响的潜力。方法慢性社交衰竭应激诱发的抑郁易感小鼠接受罗伊氏乳杆菌3（L. reuteri 3）或媒介物的口服治疗28天，并评估其行为和血清素代谢的变化。16S rRNA测序和气相色谱仪用于分析肠道菌群和短链脂肪酸（SCFA）。结果罗伊氏乳杆菌3的治疗改善了抑郁样行为，抑制了梭状芽胞杆菌和adlercreutzia的相对丰度的增加，改善了由压力引起的乳酸杆菌，同种杆菌和Sutterella丰度的降低，并显着增加了双歧杆菌的比例。罗伊氏乳杆菌3降低了抑郁症组的乙酸盐和总SCFA水平。抑郁样小鼠的血液和5-HT含量降低，但在罗伊氏乳杆菌3处理后明显改善。此外，罗伊氏乳杆菌3的施用增加了与5-羟色胺生物合成有关的酶的表达，但抑制了沿结肠和前额叶皮质中的犬尿氨酸途径的色氨酸代谢所涉及的酶的表达。结论尽管肠道菌群很复杂，但暴露于单个微生物菌株L。罗伊特氏菌3可以预防由慢性社交失败压力引起的类似抑郁的行为。罗伊氏乳杆菌3的抗抑郁作用与肠道菌群和5-羟色胺代谢改善有关。
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