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pH-dependent swelling and antibiotic release from citric acid crosslinked poly(vinyl alcohol) (PVA)/nano silver hydrogels.
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2019-12-24 , DOI: 10.1016/j.colsurfb.2019.110757 Mohammad Sabzi 1 , Mohammad Javad Afshari 1 , Masoud Babaahmadi 1 , Nima Shafagh 1
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2019-12-24 , DOI: 10.1016/j.colsurfb.2019.110757 Mohammad Sabzi 1 , Mohammad Javad Afshari 1 , Masoud Babaahmadi 1 , Nima Shafagh 1
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In this work, a pH-sensitive and antibacterial drug delivery system based on poly(vinyl alcohol) (PVA)/citric acid (CA)/Ag nanoparticles (NPs) was designed using a completely green, facile and one-step route. Interestingly, the crosslinking of PVA with CA, and in-situ formation of Ag NPs within the polymeric matrix were simultaneously and simply carried out using an annealing process without need for any toxic chemicals. The developed hydrogels were characterized by FTIR, UV-vis spectra, SEM and TEM techniques. It was found that CA not only acted as a crosslinker of PVA via esterification reaction, but also it endowed pH-responsiveness and antibacterial activity to the PVA matrix due to presence of free carboxylic acid groups on CA. Hydrogels demonstrated a pH-dependent swelling as well as drug release behavior, as the swelling ratio and the drug release at pH 7.4 were found higher than pH 1.2. Furthermore, the release of ciprofloxacin was more sustained when Ag NPs were incorporated into hydrogels. In addition, the incorporation of CA, Ag NPs and ciprofloxacin into the PVA matrix provided an effective antibacterial activity against E. coli and S. aureus microorganisms. The developed hydrogels can be considered as a promising material in the prolonged antibiotic therapy such as intestinal infection treatment.
中文翻译：
柠檬酸交联的聚乙烯醇（PVA）/纳米银水凝胶的pH依赖性溶胀和抗生素释放。
在这项工作中，使用完全绿色，简便且一步一步的方法设计了基于聚乙烯醇（PVA）/柠檬酸（CA）/银纳米颗粒（NPs）的pH敏感和抗菌药物递送系统。有趣的是，PVA与CA的交联以及在聚合物基质中原位形成Ag NP的过程同时进行，并且使用退火工艺即可轻松进行，而无需使用任何有毒化学物质。所开发的水凝胶通过FTIR，UV-可见光谱，SEM和TEM技术进行了表征。发现CA不仅通过酯化反应充当PVA的交联剂，而且由于CA上存在游离羧酸基团而赋予了pH响应性和对PVA基质的抗菌活性。水凝胶显示出pH依赖性的溶胀以及药物释放行为，因为在pH 7.4时溶胀率和药物释放高于pH 1.2。此外，将Ag NPs掺入水凝胶后，环丙沙星的释放更加持久。另外，将CA，Ag NP和环丙沙星掺入到PVA基质中提供了对大肠杆菌和金黄色葡萄球菌微生物的有效抗菌活性。所开发的水凝胶可以被认为是长期抗生素治疗（如肠道感染治疗）中的一种有前途的材料。
更新日期：2019-12-25
中文翻译：
柠檬酸交联的聚乙烯醇（PVA）/纳米银水凝胶的pH依赖性溶胀和抗生素释放。
在这项工作中，使用完全绿色，简便且一步一步的方法设计了基于聚乙烯醇（PVA）/柠檬酸（CA）/银纳米颗粒（NPs）的pH敏感和抗菌药物递送系统。有趣的是，PVA与CA的交联以及在聚合物基质中原位形成Ag NP的过程同时进行，并且使用退火工艺即可轻松进行，而无需使用任何有毒化学物质。所开发的水凝胶通过FTIR，UV-可见光谱，SEM和TEM技术进行了表征。发现CA不仅通过酯化反应充当PVA的交联剂，而且由于CA上存在游离羧酸基团而赋予了pH响应性和对PVA基质的抗菌活性。水凝胶显示出pH依赖性的溶胀以及药物释放行为，因为在pH 7.4时溶胀率和药物释放高于pH 1.2。此外，将Ag NPs掺入水凝胶后，环丙沙星的释放更加持久。另外，将CA，Ag NP和环丙沙星掺入到PVA基质中提供了对大肠杆菌和金黄色葡萄球菌微生物的有效抗菌活性。所开发的水凝胶可以被认为是长期抗生素治疗（如肠道感染治疗）中的一种有前途的材料。
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