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Neutrophil membranes coated, antibiotic agent loaded nanoparticles targeting to the lung inflammation.
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2019-12-24 , DOI: 10.1016/j.colsurfb.2019.110755 Kaiyu Wang 1 , Yiteng Lei 2 , Donglin Xia 3 , Peipei Xu 4 , Tao Zhu 5 , Zhongying Jiang 2 , Yuqiang Ma 5
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2019-12-24 , DOI: 10.1016/j.colsurfb.2019.110755 Kaiyu Wang 1 , Yiteng Lei 2 , Donglin Xia 3 , Peipei Xu 4 , Tao Zhu 5 , Zhongying Jiang 2 , Yuqiang Ma 5
Affiliation
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Natural cellular membranes, with the outstanding qualities of biocompatibility and specificity, have gained growing attentions in the system of drug delivery. Nanoparticles coated with cellular membranes are starting to be applied as drug-loaded-vehicles to target tumors. Here, neutrophil membranes were selected to apply in the treatment of inflammation because neutrophils can participate in various inflammatory responses and accumulate at inflammatory sites to eliminate pathogens. Through extracting neutrophil membranes from natural neutrophils without affecting their biological properties, nanoparticles loaded with sparfloxacin (SPX) were coated with these membranes and disguised as neutrophils. Compared with traditional nano-medicines, the neutrophil membrane-coated nanoparticles (NM-NP-SPX) possessed precise targeting ability just like the neutrophils could accumulate at inflammatory sites when inflammation burst. In addition, NM-NP-SPX could prolong the circulation time and had the property of controlled-release. Through in vivo experiments, we found that the concentration of three representative inflammatory cytokines in blood, bacteria and inflammatory cells in lungs of the mice with pneumonia reduced significantly in the initial 24 h after the injection of NM-NP-SPX, which meant that NM-NP-SPX could greatly reduce the risk of death for the patients with inflammation. Moreover, the infected lungs could recover rapidly without any side effects to other organs due to the low cytotoxicity of NM-NP-SPX against normal cells. Therefore, our developed drug delivery system has enormous advantages in treating inflammations. Not only that, this kind of bionic method may have greater value and application prospects in curing the inflammations arisen from cancers.
中文翻译：
涂有嗜中性粒细胞膜的载有抗生素的纳米颗粒靶向肺部炎症。
具有出色的生物相容性和特异性的天然细胞膜在药物输送系统中受到越来越多的关注。涂有细胞膜的纳米颗粒开始作为载药载体应用于靶向肿瘤。在这里，选择中性粒细胞膜来治疗炎症，因为中性粒细胞可以参与各种炎症反应并积聚在炎症部位以消除病原体。通过从天然嗜中性粒细胞中提取嗜中性粒细胞膜而不影响其生物学特性，负载司巴沙星（SPX）的纳米颗粒被这些膜覆盖并伪装成嗜中性粒细胞。与传统的纳米药物相比，中性粒细胞膜包被的纳米颗粒（NM-NP-SPX）具有精确的靶向能力，就像中性粒细胞在炎症爆发时会积聚在炎症部位一样。此外，NM-NP-SPX可以延长循环时间，并具有控释特性。通过体内实验，我们发现，在注射NM-NP-SPX后的最初24小时内，肺炎小鼠的血液，细菌和肺中的炎性细胞中三种代表性炎性细胞因子的浓度显着降低，这意味着NM -NP-SPX可以大大降低炎症患者的死亡风险。此外，由于NM-NP-SPX对正常细胞的低细胞毒性，被感染的肺可以迅速恢复，而不会对其他器官产生任何副作用。所以，我们开发的药物输送系统在治疗炎症方面具有巨大优势。不仅如此，这种仿生方法在治疗癌症引起的炎症方面可能具有更大的价值和应用前景。
更新日期：2019-12-25
中文翻译：
涂有嗜中性粒细胞膜的载有抗生素的纳米颗粒靶向肺部炎症。
具有出色的生物相容性和特异性的天然细胞膜在药物输送系统中受到越来越多的关注。涂有细胞膜的纳米颗粒开始作为载药载体应用于靶向肿瘤。在这里，选择中性粒细胞膜来治疗炎症，因为中性粒细胞可以参与各种炎症反应并积聚在炎症部位以消除病原体。通过从天然嗜中性粒细胞中提取嗜中性粒细胞膜而不影响其生物学特性，负载司巴沙星（SPX）的纳米颗粒被这些膜覆盖并伪装成嗜中性粒细胞。与传统的纳米药物相比，中性粒细胞膜包被的纳米颗粒（NM-NP-SPX）具有精确的靶向能力，就像中性粒细胞在炎症爆发时会积聚在炎症部位一样。此外，NM-NP-SPX可以延长循环时间，并具有控释特性。通过体内实验，我们发现，在注射NM-NP-SPX后的最初24小时内，肺炎小鼠的血液，细菌和肺中的炎性细胞中三种代表性炎性细胞因子的浓度显着降低，这意味着NM -NP-SPX可以大大降低炎症患者的死亡风险。此外，由于NM-NP-SPX对正常细胞的低细胞毒性，被感染的肺可以迅速恢复，而不会对其他器官产生任何副作用。所以，我们开发的药物输送系统在治疗炎症方面具有巨大优势。不仅如此，这种仿生方法在治疗癌症引起的炎症方面可能具有更大的价值和应用前景。
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