Autoresuscitation is an important cardiorespiratory protective mechanism that allows neonatal mammals to recover from primary apnea. It begins with hypoxia-induced gasping and ends, if successful, with the recovery of rhythmic breathing and normal heart rate. Many factors influence the efficacy of autoresuscitation, including the availability of serotonin (5-HT) in the brain. Since the early 2000's, there has been mounting interest in the role of 5-HT in promoting autoresuscitation, driven in large part by the recognition that both failed autoresuscitation and a deficiency of central 5-HT correlate with Sudden Infant Death Syndrome in humans. Within this timeframe, newly developed animal models with a central 5-HT deficiency have examined experimentally the role of 5-HT in autoresuscitation capability. The purpose of this review is to discuss some of the methodological considerations associated with 5-HT-deficient animal models, to summarize major findings arising from their use, and to highlight several key issues related to 5-HT involvement in gasping and the autoresuscitation response.

中文翻译：

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哺乳动物新生儿中枢5-羟色胺和自动复苏的能力。

自动复苏是一种重要的心肺保护机制，可使新生哺乳动物从原发性呼吸暂停中恢复过来。它以缺氧引起的喘息开始，如果成功，则以有节奏的呼吸恢复和正常心率结束。许多因素都会影响自动复苏的效果，包括大脑中5-羟色胺（5-HT）的可用性。自2000年代初以来，人们对5-HT在促进自动复苏中的作用越来越感兴趣，这在很大程度上是由于认识到自动复苏失败和中枢5-HT缺乏均与人类婴儿猝死综合症有关。在此时间范围内，新开发的具有5-HT中枢缺乏症的动物模型已通过实验检查了5-HT在自动复苏功能中的作用。