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Antibody recognition of bacterial surfaces and extracellular polysaccharides.
Current Opinion in Structural Biology ( IF 6.1 ) Pub Date : 2019-12-21 , DOI: 10.1016/j.sbi.2019.12.001 Caroline Soliman 1 , Gerald B Pier 2 , Paul A Ramsland 3
Current Opinion in Structural Biology ( IF 6.1 ) Pub Date : 2019-12-21 , DOI: 10.1016/j.sbi.2019.12.001 Caroline Soliman 1 , Gerald B Pier 2 , Paul A Ramsland 3
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Because of the ongoing increase in antibiotic-resistant microbes, new strategies such as therapeutic antibodies and effective vaccines are required. Bacterial carbohydrates are known to be particularly antigenic, and several monoclonal antibodies that target bacterial polysaccharides have been generated, with more in current development. This review examines the known 3D crystal structures of anti-bacterial antibodies and the structural basis for carbohydrate recognition and explores the potential mechanisms for antibody-dependent bacterial cell death. Understanding the key interactions between an antibody and its polysaccharide target on the surface of bacteria or in biofilms can provide essential information for the development of more specific and effective antibody therapeutics as well as carbohydrate-based vaccines.
中文翻译：
细菌表面和细胞外多糖的抗体识别。
由于抗生素抗性微生物的持续增加，需要诸如治疗性抗体和有效疫苗的新策略。已知细菌碳水化合物特别具有抗原性，并且已经产生了几种靶向细菌多糖的单克隆抗体，并且目前正在开发中。这项审查审查了抗菌抗体的已知3D晶体结构和碳水化合物识别的结构基础，并探讨了抗体依赖性细菌细胞死亡的潜在机制。了解抗体及其在细菌表面或生物膜中的多糖靶标之间的关键相互作用可以为开发更特异性和更有效的抗体疗法以及基于碳水化合物的疫苗提供重要信息。
更新日期：2019-12-25
中文翻译：
细菌表面和细胞外多糖的抗体识别。
由于抗生素抗性微生物的持续增加，需要诸如治疗性抗体和有效疫苗的新策略。已知细菌碳水化合物特别具有抗原性，并且已经产生了几种靶向细菌多糖的单克隆抗体，并且目前正在开发中。这项审查审查了抗菌抗体的已知3D晶体结构和碳水化合物识别的结构基础，并探讨了抗体依赖性细菌细胞死亡的潜在机制。了解抗体及其在细菌表面或生物膜中的多糖靶标之间的关键相互作用可以为开发更特异性和更有效的抗体疗法以及基于碳水化合物的疫苗提供重要信息。
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