Novel combined biological antiviral agents Cytosinpeptidemycin and Chitosan oligosaccharide induced host resistance and changed movement protein subcellular localization of tobacco mosaic virus,Pesticide Biochemistry and Physiology

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Novel combined biological antiviral agents Cytosinpeptidemycin and Chitosan oligosaccharide induced host resistance and changed movement protein subcellular localization of tobacco mosaic virus
Pesticide Biochemistry and Physiology ( IF 4.2 ) Pub Date : 2020-03-01 , DOI: 10.1016/j.pestbp.2019.12.006
Yi Guo ₁ , Yunqi Dong ₂ , Chuantao Xu ₃ , Qiang Xie ₄ , Yunbo Xie ₅ , Zihao Xia ₁ , Mengnan An ₁ , Yuanhua Wu ₁

Affiliation

Plant viral diseases cause severe economic losses in agricultural production. Development of microorganism-derived antiviral agents provides an alternative strategy to efficiently control plant viral diseases. In this study, the antiviral effect and mechanism of a combined biological agent Cytosinpeptidemycin and Chitosan oligosaccharide (CytPM-COS) were investigated. CytPM-COS effectively inhibited tobacco mosaic virus (TMV) in Nicotiana glutinosa, suppressed viral RNA and CP accumulation in BY-2 protoplast and affected the subcellular localization as well as punctate formation of TMV MP in N. benthamiana leaves. In addition, CytPM-COS triggered reactive oxygen species (ROS) production and induced up-regulation of various defense responsive genes including PR-1, PR-5, FLS2, Hsp70. Our results indicated that CytPM-COS can potentially act as a pesticide for integrated control of plant viruses in the future.

中文翻译：

新型联合生物抗病毒剂胞嘧啶肽霉素和壳寡糖诱导宿主抵抗并改变烟草花叶病毒运动蛋白亚细胞定位

植物病毒病给农业生产带来严重的经济损失。微生物源抗病毒剂的开发提供了有效控制植物病毒病的替代策略。在本研究中，研究了联合生物制剂胞嘧啶肽霉素和壳寡糖（CytPM-COS）的抗病毒作用和机制。 CytPM-COS 有效抑制烟草花叶病毒 (TMV)，抑制 BY-2 原生质体中病毒 RNA 和 CP 积累，影响本塞姆氏烟草叶片中 TMV MP 的亚细胞定位和点状形成。此外，CytPM-COS 触发活性氧 (ROS) 产生并诱导各种防御反应基因（包括 PR-1、PR-5、FLS2、Hsp70）上调。我们的结果表明，CytPM-COS 未来有可能作为农药综合控制植物病毒。

更新日期：2020-03-01

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