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Research on a kind of biocompatible molecularly imprinted materials with silybin controlled release based on pH/temperature dual responses
Reactive & Functional Polymers ( IF 4.5 ) Pub Date : 2019-12-25 , DOI: 10.1016/j.reactfunctpolym.2019.104449
Ni Tan , Kang Ji , Dianxiong He , Sen Liao , Leqing He , Jingwen Han , Can Chen , Yaqing Liu

Silybin, a hepatoprotective active natural ingredient, was used as the template, methyl acrylic acid (MAA) as the functional monomer, n-isopropyl acrylamide (NIPAm) as the thermal response monomer, magnetic core Fe3O4@[email protected]@BiBB coated by biocompatible chitosan as the carrier, and a kind of silybin molecularly imprinted materials (MMIPs) based on pH/temperature dual responses were prepared by electron transfer activation regenerative catalyst atom transfer radical polymerization (ARGET ATRP). The synthesized material was characterized by FT-IR, TGA, SEM, XRD, VSM, and XPS, and the loading behavior of silybin in MMIPs could be explained by the pseudo-second-order kinetic model. The selectivity factor α (2.636) and the relative selectivity factor β (2.468) indicated MMIPs had good specific recognition ability for silybin. In addition, a series of experimental data displayed MMIPs had many other excellent characteristics such as adsorption property, swelling performance, biocompatibility, degradability, stability, reproducibility and so on. The cumulative release rates of MMIPs could reach 29%, 23% and 25% in the media of pH 1.0, 7.4 and 8.2 at 37.5 °C, resepectively, and when the temperature was raised to 43 °C, the release rate of MMIPs in solution (pH 7.4) reached 49%, which indicated that the carrier material had good pH/temperature dual responses.



中文翻译:

基于pH /温度双重响应的水飞蓟宾控释生物相容性分子印迹材料的研究

保肝活性天然成分水飞蓟宾被用作模板,甲基丙烯酸(MAA)作为功能单体,正异丙基丙烯酰胺(NIPAm)作为热响应单体,磁芯Fe 3 O 4以生物相容性壳聚糖为载体包覆BiBB,并通过电子转移活化再生催化剂原子转移自由基聚合(ARGET ATRP)制备了一种基于pH /温度双重反应的水飞蓟宾分子印迹材料(MMIPs)。通过FT-IR,TGA,SEM,XRD,VSM和XPS对合成的材料进行了表征,并用伪二级动力学模型解释了水飞蓟宾在MMIPs中的负载行为。选择性因子α(2.636)和相对选择性因子β(2.468)表明MMIP对水飞蓟宾具有良好的特异性识别能力。此外,一系列实验数据表明,MMIPs具有许多其他优异的特性,如吸附性能,溶胀性能,生物相容性,可降解性,稳定性,可重复性等。

更新日期:2019-12-25
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