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Switching from endogenous to exogenous delivery of a model drug to DNA through micellar engineering.
Journal of Photochemistry and Photobiology B: Biology ( IF 3.9 ) Pub Date : 2019-12-25 , DOI: 10.1016/j.jphotobiol.2019.111765
Pronab Kundu 1 , Sinjan Das 1 , Nitin Chattopadhyay 1
Affiliation  

A potential strategy has been demonstrated, for the first time, for switching the mode of delivery of drugs or small molecular systems from endogenous to exogenous, simply by engineering the chain length of micellar carriers. Ethidium bromide (EB) is exploited as the model drug which has been successfully delivered to natural DNA through endogenous and exogenous modes by tuning the chain length of anionic sodium n-alkyl sulfate micelles. β-cyclodextrin (β-CD) is exploited as an extrinsic stimulant for the exogenous delivery of EB to DNA. Multi-spectroscopic techniques involving absorption, emission, fluorescence anisotropy, fluorescence decay analysis, circular dichroism, DNA helix melting etc. have established tuning of the delivery mode between endogenous and exogenous. Differential binding affinity of the model drug with different micelles of varying chain length relative to that with DNA is capitalized to make the switching feasible. Although endogenous mode avoids external stimulant and associated problems, a regulation of the stimulant concentration makes the other mode controllable and quantitative. With appropriate choice of carrier micelle and modulation of this developed strategy can radically change the therapeutic research enabling one to take a control over the drug delivery mode to exploit the advantage of one or the other selectively, whenever required.

中文翻译:

通过胶束工程从模型药物向DNA的内源性转移到外源性转移。

仅仅通过设计胶束载体的链长,就首次展示了一种潜在的策略,可以将药物或小分子系统的递送方式从内源性转换为外源性。溴化乙锭(EB)被用作模型药物,通过调节阴离子正烷基硫酸钠钠胶束的链长,已通过内源性和外源性模式成功地递送至天然DNA。β-环糊精(β-CD)被用作外源性兴奋剂,用于将EB对外源传递至DNA。涉及吸收,发射,荧光各向异性,荧光衰减分析,圆二色性,DNA螺旋解链等的多光谱技术已经建立了内源性和外源性之间传递模式的调整。相对于DNA,具有不同链长的不同胶束的模型药物的差异结合亲和力被大写以使切换可行。尽管内源模式避免了外部刺激物和相关问题,但是刺激物浓度的调节使得另一种模式可控且定量。附有载体胶束和这个发达策略调制的合适的选择可以从根本上改变治疗研究使一个接管药物递送模式的控制以利用一种或另一种的选择性优点,需要每当。刺激剂浓度的调节使另一种模式可控和定量。附有载体胶束和这个发达策略调制的合适的选择可以从根本上改变治疗研究使一个接管药物递送模式的控制以利用一种或另一种的选择性优点,需要每当。刺激剂浓度的调节使另一种模式可控和定量。附有载体胶束和这个发达策略调制的合适的选择可以从根本上改变治疗研究使一个接管药物递送模式的控制以利用一种或另一种的选择性优点,需要每当。
更新日期:2019-12-25
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