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Excellent capacity of singlet oxygen generation by gadolinium labelled sinoporphyrin sodium
Journal of Luminescence ( IF 3.3 ) Pub Date : 2020-03-01 , DOI: 10.1016/j.jlumin.2019.116972
Ting Liu , Honglin Zhang , Hua Zhao , Zhiguo Zhang , Ye Tian

Abstract The singlet oxygen quantum yield (ΦΔ) represents the ability of a photosensitizer to produce the photodynamic therapy effect. However, the pursuiting of strong phosphorescence properties of metalloporphyrins hindered the fact that they may have high ΦΔ. In this paper, we studied the effect of imidazole, a small organic molecule used as a solvent in the synthesis of multifunctional photosensitizers (PSs), on the ΦΔ of the PS, gadolinium-containing sinoporphyrin sodium (Gd-DVDMS), using a relative method with Rose Bengal as the reference and 1,3-diphenylisobenzofuran as the singlet oxygen trapping reagent. After completely removal of imidazole by dialysis, the ΦΔ value of Gd-DVDMS was obtained to be as high as 0.97. In addition, with an increase in the imidazole concentration, the ΦΔ of Gd-DVDMS gradually decreased, and stabilized at a value of 0.37. To understand the above phenomenon, the ultraviolet–visible absorption and photoluminescence spectra of Gd-DVDMS for different imidazole concentrations were analyzed. The triplet state quantum yield of Gd-DVDMS was constant, while the O2 quenching rate of the triplet state decreased; this indicated that the energy exchange between the PS and O2 was reduced by imidazole. We deduced that decrease in ΦΔ was attributable to the increase in the distance between Gd-DVDMS and O2, owing to imidazole wrapping around Gd-DVDMS. It is speculated that as the wrapping progressed, the effects of the dissolution and attachment of imidazole reached a balance, and hence, the ΦΔ remained constant.

中文翻译:

钆标记的卟啉钠具有优异的单线态氧生成能力

摘要 单线态氧量子产率(ΦΔ)代表光敏剂产生光动力治疗效果的能力。然而,对金属卟啉强磷光特性的追求阻碍了它们可能具有高 ΦΔ 的事实。在本文中,我们研究了在多功能光敏剂 (PSs) 合成中用作溶剂的有机小分子咪唑对含钆的 PS 的 ΦΔ (Gd-DVDMS) 的影响。方法以玫瑰红为参比,1,3-二苯基异苯并呋喃为单线态氧捕集剂。通过透析完全去除咪唑后,Gd-DVDMS的ΦΔ值高达0.97。此外,随着咪唑浓度的增加,Gd-DVDMS的ΦΔ逐渐减小,并稳定在 0.37 的值。为了理解上述现象,分析了不同咪唑浓度下 Gd-DVDMS 的紫外-可见吸收和光致发光光谱。Gd-DVDMS的三重态量子产率不变,而三重态的O2猝灭率降低;这表明 PS 和 O2 之间的能量交换被咪唑减少了。我们推断 ΦΔ 的减小归因于 Gd-DVDMS 和 O2 之间距离的增加,这是由于咪唑包裹在 Gd-DVDMS 周围。推测随着包裹的进行,咪唑的溶解和附着作用达到平衡,因此ΦΔ保持恒定。分析了不同咪唑浓度下 Gd-DVDMS 的紫外-可见吸收和光致发光光谱。Gd-DVDMS的三重态量子产率不变,而三重态的O2猝灭率降低;这表明咪唑减少了 PS 和 O2 之间的能量交换。我们推断 ΦΔ 的减小归因于 Gd-DVDMS 和 O2 之间距离的增加,这是由于咪唑包裹在 Gd-DVDMS 周围。推测随着包裹的进行,咪唑的溶解和附着作用达到平衡,因此ΦΔ保持恒定。分析了不同咪唑浓度下 Gd-DVDMS 的紫外-可见吸收和光致发光光谱。Gd-DVDMS的三重态量子产率不变,而三重态的O2猝灭率降低;这表明咪唑减少了 PS 和 O2 之间的能量交换。我们推断 ΦΔ 的减小归因于 Gd-DVDMS 和 O2 之间距离的增加,这是由于咪唑包裹在 Gd-DVDMS 周围。推测随着包裹的进行,咪唑的溶解和附着作用达到平衡,因此ΦΔ保持恒定。这表明 PS 和 O2 之间的能量交换被咪唑减少了。我们推断 ΦΔ 的减小归因于 Gd-DVDMS 和 O2 之间距离的增加,这是由于咪唑包裹在 Gd-DVDMS 周围。推测随着包裹的进行,咪唑的溶解和附着作用达到平衡,因此ΦΔ保持恒定。这表明咪唑减少了 PS 和 O2 之间的能量交换。我们推断 ΦΔ 的减小归因于 Gd-DVDMS 和 O2 之间距离的增加,这是由于咪唑包裹在 Gd-DVDMS 周围。推测随着包裹的进行,咪唑的溶解和附着作用达到平衡,因此ΦΔ保持恒定。
更新日期:2020-03-01
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