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Bignanoside A "A new neolignan glucoside" and bignanoside B "A new iridoid glucoside" from Bignonia binata leaves
Phytochemistry Letters ( IF 1.3 ) Pub Date : 2019-12-23 , DOI: 10.1016/j.phytol.2019.12.009
Basma Khalaf Mahmoud , Mamdouh Nabil Samy , Ashraf Nageeb Elsayed Hamed , Usama Ramadan Abdelmohsen , Dina Hajjar , Yoshi Yamano , Sachiko Sugimoto , Katsuyoshi Matsunami , Mohamed Salah Kamel

One new neolignan glucoside; bignanoside A (1) and one new iridoid glucoside; bignanoside B (2), and one new lignan rhamnoside; (-)-1yoniresinol 3α-O-α-L-rhamnopyranoside (3) reported for the first time, alongside with seven known compounds were isolated from Bignonia binata leaves. The structures of the isolated compounds were elucidated by various spectroscopic methods, including 1D and 2D NMR experiments, as well as HR-ESI-MS. Compound 2 had a potent DPPH radical scavenging activity with IC50 value of 18.34 ± 0.81 μM. Likewise, compounds 4 and 9 exhibited antitrypanosomal activity with IC50 value of 29.12 ± 1.21 and 17.80 ± 0.32 μM, respectively, against Trypanosoma brucei brucei S427.



中文翻译:

Bignanoside A“的新木脂素苷”及bignanoside B“一个新的环烯醚萜苷”,从紫葳龙须草

一种新的新木脂苷苷;比格诺苷A(1)和一种新的虹彩苷苷;比格诺苷B(2)和一种新的木脂素鼠李糖苷;( - ) - 3 1yoniresinol α - ø - α -L吡喃鼠李糖苷(3)报告首次,沿着与七个已知化合物从分离紫葳龙须草叶。通过各种光谱方法(包括1D和2D NMR实验以及HR-ESI-MS)阐明了分离出的化合物的结构。化合物2具有与IC的有效DPPH自由基清除活性50 18.34±0.81值μ M.同样,化合物49显示出抗锥体虫活性,IC 50 29.12±1.21 17.80和±0.32的值μ分别用M,对布氏锥虫布氏S427。

更新日期:2019-12-25
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