Teleost IgD+IgM- B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles.,Cell Reports

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Teleost IgD+IgM- B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles.
Cell Reports ( IF 7.5 ) Pub Date : 2019-12-24 , DOI: 10.1016/j.celrep.2019.11.101
Pedro Perdiguero ₁ , Alba Martín-Martín ₁ , Ottavia Benedicenti ₁ , Patricia Díaz-Rosales ₁ , Esther Morel ₁ , Estefanía Muñoz-Atienza ₁ , Mónica García-Flores ₁ , Rocío Simón ₁ , Irene Soleto ₁ , Andrea Cerutti ₂ , Carolina Tafalla ₁

Affiliation

Immunoglobulin D (IgD) is an ancient antibody with dual membrane-bound and fluid-phase antigen receptor functions. The biology of secreted IgD remains elusive. Here, we demonstrate that teleost IgD+IgM- plasmablasts constitute a major lymphocyte population in some mucosal surfaces, including the gut mucosa. Remarkably, secreted IgD binds to gut commensal bacteria, which in turn stimulate IgD gene transcription in gut B cells. Accordingly, secreted IgD from gut as well as gill mucosae, but not the spleen, show a V(D)J gene configuration consistent with microbiota-driven clonal expansion and diversification, including mild somatic hypermutation. By showing that secreted IgD establishes a mutualistic relationship with commensals, our findings suggest that secreted IgD may play an evolutionary conserved role in mucosal homeostasis.

中文翻译：

在没有淋巴滤泡的情况下，Teleost IgD + IgM- B细胞会克隆克隆扩张和轻度突变的肠道IgD反应。

免疫球蛋白D（IgD）是一种古老的抗体，具有双重膜结合和液相抗原受体功能。分泌的IgD的生物学仍然难以捉摸。在这里，我们证明硬骨IgD + IgM-浆母细胞在包括肠粘膜在内的某些粘膜表面构成了主要的淋巴细胞群。值得注意的是，分泌的IgD与肠道共生细菌结合，从而刺激肠道B细胞中的IgD基因转录。因此，从肠道以及腮黏膜而非脾脏分泌的IgD显示出V（D）J基因构型，与微生物群驱动的克隆扩增和多样化（包括轻度的体细胞超突变）相一致。通过证明分泌的IgD与共生关系建立了相互关系，我们的发现表明，分泌的IgD可能在粘膜内稳态中具有进化的保守作用。

更新日期：2019-12-25

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