An oxidative sp³ C–H bond of methyl-azaheteroarenes protocol was reported for the synthesis of 1,3,4-oxadiazoles via [4 + 1] annulation with hydrazides. This protocol enables 1,3,4-oxadiazole and quinoline linked diheterocycles via selective oxidation of sp³ C–H bond of methyl-azaheteroarenes in the presence of I₂-DMSO. The reaction has a broad substrate scope and good functional group tolerance for methyl-azaheteroarenes and hydrazides.

中文翻译：

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通过碘轻松合成1,3,4-恶二唑，促进了甲基氮杂叠氮芳烃和酰肼的氧化环化反应

据报道，甲基[azazeteroarenes]协议的氧化sp ³ C–H键可通过[4 +1]酰肼环合反应合成1,3,4-恶二唑。该方案通过在I ₂ -DMSO存在下对甲基-氮杂杂环芳烃的sp ³ C–H键进行选择性氧化来实现1,3,4-恶二唑和喹啉连接的二杂环。该反应具有广泛的底物范围，并且对甲基-氮杂环杂芳烃和酰肼具有良好的官能团耐受性。