DNA double-strand breaks (DSBs) elicit major chromatin changes. Using super-resolution microscopy in human cells, Ochs et al. unveil that the DSB response protein 53BP1 and its effector RIF1 organize DSB-flanking chromatin into circular micro-domains. These structures control the spatial distribution of DSB repair factors safeguarding genome integrity.

中文翻译：

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围绕DNA断裂重塑染色质结构。

DNA双链断裂（DSB）引起主要的染色质变化。Ochs等人在人体细胞中使用超分辨率显微镜。揭示了DSB反应蛋白53BP1及其效应子RIF1将DSB侧染染色质组织成环状微结构域。这些结构控制着DSB修复因子的空间分布，从而保护了基因组的完整性。