BACKGROUND Studies have indicated that Plantago major L. (P. major) has therapeutic properties, such as anti-inflammatory, antioxidant, antifungal, immunostimulatory, and tissue regeneration. This plant species is assumed to provide potent tissue repair and healing in treatments of skin wound injuries, but the understanding of its effectiveness is still unclear. The systematic review proposed herein aims to assess effectiveness of P. major for wound healing in animal models. METHODS We will conduct database searches in BVS, PubMed, Scopus, Web of Science, CINAHL, and CABDirect. Reviewers will independently evaluate titles, abstracts, and full-text articles retrieved from databases to identify potentially eligible studies. Relevant articles will be assessed for risk of bias and quality. The database searches will include analysis of wound healing rate through macroscopic evaluation, photo images, or calculation of the wound area retraction until the wound closure. Relevant data will be compiled for the capability and effectiveness of P. major treatments in accelerating wound healing. Random effects meta-analysis models will be employed to compare among groups based on outcome variables from studies reporting sufficient high-quality data. DISCUSSION Results of this systematic review will be presented in a narrative synthesis form. They will provide a summary and clear understanding of the relevant current questions and evidences directly related to P. major effective tissue repair and healing. Outcomes of this systematic review will contribute with important information that could benefit future research efforts and potential applicability in humans. SYSTEMATIC REVIEW REGISTRATION PROSPERO CRD42019121962.

中文翻译：

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系统评价车前子在加速动物模型伤口愈合方面的有效性的方案。

背景研究表明车前子（P.major）具有治疗特性，例如抗炎、抗氧化、抗真菌、免疫刺激和组织再生。人们认为这种植物能够在皮肤伤口的治疗中提供有效的组织修复和愈合作用，但对其有效性的了解仍不清楚。本文提出的系统评价旨在评估大蠹在动物模型中伤口愈合的有效性。方法 我们将在 BVS、PubMed、Scopus、Web of Science、CINAHL 和 CABDirect 中进行数据库检索。审稿人将独立评估从数据库检索的标题、摘要和全文文章，以识别潜在的合格研究。将评估相关文章的偏倚风险和质量。数据库搜索将包括通过宏观评估、照片图像或计算伤口闭合前的伤口面积收缩来分析伤口愈合率。将收集相关数据，以了解大蠹治疗加速伤口愈合的能力和有效性。将采用随机效应荟萃分析模型，根据报告足够高质量数据的研究的结果变量，对各组之间进行比较。讨论 本次系统评价的结果将以叙述性综合形式呈现。他们将对当前与大假单胞菌有效组织修复和愈合直接相关的相关问题和证据进行总结和清晰的理解。这次系统评价的结果将提供重要信息，这些信息可能有利于未来的研究工作和对人类的潜在适用性。系统审查注册 PROSPERO CRD42019121962。