BACKGROUND Reduced glomerular filtration rate and increased asymmetric dimethylarginine (ADMA) are prevalent in elderly people. However, most of the studies that have examined the association between the two conditions were performed in patients with renal dysfunction, but not in the general elderly population. Thus, we investigated an association between estimated glomerular filtration rate (eGFR) and ADMA concentration among community-dwelling older Koreans. METHODS A cross-sectional study was conducted on 269 men and 382 women (mean age, 71.6 years) enrolled in the Korean Social Life, Health, and Aging Project (KSHAP), a population-based cohort study of health determinants in elderly Koreans. We calculated eGFR using chronic kidney disease- Epidemiology Collaboration Group (CKD-EPI) equation. ADMA concentration was measured by an enzyme-linked immunosorbent assay. The association between eGFR and ADMA concentrations was analyzed by multiple linear regression models. RESULTS The mean ADMA was significantly higher in people with eGFR< 60 mL/min/1.73m2 (0.691 μmol/L) than in those with eGFR≥60 mL/min/1.73m2 (0.667 μmol/L, p = 0.013). The negative correlations between eGFR level and ADMA concentrations were significant in men and women after adjusted age. After adjusting for potential confounders which were sex, age, body surface, blood pressure, total and HDL cholesterol, diabetes, smoking, and drinking, eGFR levels were inversely associated with ADMA concentrations both in men (β = - 0.0015, p = 0.005) and women (β = - 0.001, p = 0.039). CONCLUSION Our findings suggest that an inverse association exists between eGFR and ADMA concentrations among the Korean elderly in a rural community.

中文翻译：

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农村社区老年人的估计肾小球滤过率（eGFR）与不对称二甲基精氨酸（ADMA）浓度之间的关联：一项横断面研究。

背景技术降低肾小球滤过率和增加不对称二甲基精氨酸（ADMA）在老年人中很普遍。但是，大多数检查这两种情况之间关系的研究都是在肾功能不全的患者中进行的，而不是在一般的老年人口中进行的。因此，我们调查了居住在社区中的老年人中估计的肾小球滤过率（eGFR）与ADMA浓度之间的关联。方法对韩国社会生活，健康与老龄化项目（KSHAP）中的269名男性和382名女性（平均年龄71.6岁）进行了横断面研究，这是一项基于人群的韩国老年人健康决定因素队列研究。我们使用慢性肾脏病-流行病学协作组（CKD-EPI）公式计算了eGFR。通过酶联免疫吸附测定法测量ADMA浓度。eGFR和ADMA浓度之间的关联通过多个线性回归模型进行了分析。结果eGFR <60 mL / min / 1.73m2（0.691μmol/ L）的人的平均ADMA显着高于eGFR≥60mL / min / 1.73m2（0.667μmol/ L，p = 0.013）的人。调整年龄后的男性和女性，eGFR水平与ADMA浓度之间呈负相关。在调整了性别，年龄，体表，血压，总胆固醇和高密度脂蛋白胆固醇，糖尿病，吸烟和饮酒的潜在混杂因素后，男性的eGFR水平与ADMA浓度呈负相关（β=-0.0015，p = 0.005）和女性（β=-0.001，p = 0.039）。