Post-synthesis strategy to integrate porphyrinic metal-organic frameworks with CuS NPs for synergistic enhanced photo-therapy.,Journal of Materials Chemistry B

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Post-synthesis strategy to integrate porphyrinic metal-organic frameworks with CuS NPs for synergistic enhanced photo-therapy.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-01-08 , DOI: 10.1039/c9tb02597a
Xiaochun Hu ₁ , Yonglin Lu ₂ , Lulu Zhou ₁ , Lv Chen ₂ , Tianming Yao ₁ , Shujing Liang ₂ , Junyi Han ₃ , Chunyan Dong ₂ , Shuo Shi ₁

Affiliation

Multifunctional nanotheranostic systems with both therapeutic and imaging functions are highly desired for the development of more effective and less toxic anti-tumor drugs. Herein, a simple but effective method is reported to fabricate a novel PCN-CuS-FA-ICG-based nanoplatform for dual-modal imaging-guided synergistic photothermal/photodynamic therapy. Porphyrinic metal-organic frameworks with CuS NPs are obtained in aqueous solution via a simple post-synthesis strategy. Furthermore, to obtain a more effective therapy, indocyanine green (ICG) was incorporated into the multifunctional theranostic platform to promote the photothermal therapeutic effect. The as-prepared PCN-CuS-FA-ICG not only exhibits an excellent 1O2 generation efficiency under 650 nm irradiation to achieve remarkable photodynamic cell killing, but also presents outstanding photothermal conversion under 808 nm irradiation to destroy tumor tissues by hyperthermia. In particular, the nanotherapeutic agent realized fluorescence and thermal imaging dual-modal imaging-guided cancer treatment. Meanwhile, in vivo experiments confirmed the evident accumulation of nanoparticles (NPs) at local tumors, and tumor growth was inhibited obviously via synergistic photothermal/photodynamic therapy with negligible side effects.

中文翻译：

合成后策略将卟啉金属有机骨架与CuS NPs整合在一起以实现协同增强的光疗。

迫切需要具有治疗和成像功能的多功能纳米治疗系统，以开发更有效和毒性更小的抗肿瘤药物。在此，据报道一种简单而有效的方法来制造用于双模态成像引导的协同光热/光动力疗法的新颖的基于PCN-CuS-FA-ICG的纳米平台。通过简单的后合成策略，可在水溶液中获得具有CuS NP的卟啉金属有机骨架。此外，为了获得更有效的治疗方法，将吲哚菁绿（ICG）掺入多功能诊疗平台中以促进光热治疗效果。如此制备的PCN-CuS-FA-ICG不仅在650 nm辐射下表现出出色的1O2生成效率，还可以实现出色的光动力细胞杀伤力，而且在808 nm辐射下也表现出出色的光热转换能力，可以通过高温破坏肿瘤组织。特别地，纳米治疗剂实现了荧光和热成像双峰成像引导的癌症治疗。同时，体内实验证实了纳米颗粒（NPs）在局部肿瘤上的明显积聚，并且通过协同的光热/光动力疗法可明显抑制肿瘤生长，且副作用可忽略不计。

更新日期：2020-02-13

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