Modulation of saliva pattern and accurate detection of ovulation using an electrolyte pre-deposition-based method: a pilot study.,Analyst

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Modulation of saliva pattern and accurate detection of ovulation using an electrolyte pre-deposition-based method: a pilot study.
Analyst ( IF 3.6 ) Pub Date : 2020-01-06 , DOI: 10.1039/c9an02169h
Eunji Lee ₁ , Iljeok Kim ₁ , Hyoryung Nam ₂ , Hyungkook Jeon ₁ , Geunbae Lim ₁

Affiliation

We developed an electrolyte pre-deposition-based saliva pattern modulation method to detect ovulation with high accuracy and reliability. Ovulation tests using human saliva have advantages in terms of the earlier ovulation detection and more convenient sample collection procedure; however, accuracy is low, which is a critical limitation given that the concentrations of salivary constituents can vary depending on the health status of the tested individual and subjective user judgement of the test result. In this study, we quantitatively analyzed saliva patterns according to the concentrations of electrolytes and proteins in the ovulation test and found that changes in the saliva pattern during the ovulatory period can be controlled by sodium chloride (NaCl) pre-deposition, which directly affects the accuracy of ovulation detection. The 100 nmol NaCl pre-deposition condition proved optimal, being two-fold more sensitive to changes in saliva pattern versus the non-pre-deposition condition (accuracy of ovulation detection = 66.6% and 33.3%, respectively). Although accuracy remained insufficient for actual applications compared to the urine-based ovulation detection method, we expect that the electrolyte pre-deposition method will greatly contribute to enhancing the performance of saliva-based ovulation detection tests, toward a commercially satisfactory level of accuracy.

中文翻译：

使用基于电解质预沉积的方法调节唾液模式并精确检测排卵：一项试点研究。

我们开发了一种基于电解质预沉积的唾液模式调制方法，以高精度和高可靠性检测排卵。使用人类唾液进行排卵测试在早期排卵检测和更方便的样品采集程序方面具有优势。但是，准确性低，这是一个关键限制，因为唾液成分的浓度会根据被测人员的健康状况和用户对测试结果的主观判断而变化。在这项研究中，我们根据排卵测试中电解质和蛋白质的浓度对唾液模式进行了定量分析，发现排卵期唾液模式的变化可以通过氯化钠（NaCl）的预先沉积来控制，这直接影响了排卵检测的准确性。100 nmol NaCl预先沉积条件证明是最佳的，对唾液模式变化的敏感性是非预先沉积条件的两倍（排卵检测的准确度分别为66.6％和33.3％）。尽管与基于尿液的排卵检测方法相比，准确性仍不足以用于实际应用，但我们期望电解质预沉积方法将大大有助于提高基于唾液的排卵检测测试的性能，从而达到商业上令人满意的准确性水平。

更新日期：2020-03-03

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