MYB20, MYB42, MYB43, and MYB85 Regulate Phenylalanine and Lignin Biosynthesis during Secondary Cell Wall Formation.,Plant Physiology

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MYB20, MYB42, MYB43, and MYB85 Regulate Phenylalanine and Lignin Biosynthesis during Secondary Cell Wall Formation.
Plant Physiology ( IF 6.5 ) Pub Date : 2019-12-23 , DOI: 10.1104/pp.19.01070
Pan Geng ₁ , Su Zhang _{1,

2} , Jinyue Liu ₁ , Cuihuan Zhao ₃ , Jie Wu _{1,

2} , Yingping Cao ₄ , Chunxiang Fu ₄ , Xue Han ₅ , Hang He ₅ , Qiao Zhao ₃

Affiliation

Lignin is a phenylpropanoid-derived polymer that functions as a major component of cell walls in plant vascular tissues. Biosynthesis of the aromatic amino acid Phe provides precursors for many secondary metabolites, including lignins and flavonoids. Here, we discovered that MYB transcription factors MYB20, MYB42, MYB43, and MYB85 are transcriptional regulators that directly activate lignin biosynthesis genes and Phe biosynthesis genes during secondary wall formation in Arabidopsis (Arabidopsis thaliana). Disruption of MYB20, MYB42, MYB43, and MYB85 resulted in growth development defects and substantial reductions in lignin biosynthesis. In addition, our data showed that these MYB proteins directly activated transcriptional repressors that specifically inhibit flavonoid biosynthesis, which competes with lignin biosynthesis for Phe precursors. Together, our results provide important insights into the molecular framework for the lignin biosynthesis pathway.

中文翻译：

MYB20，MYB42，MYB43和MYB85调节次生细胞壁形成过程中苯丙氨酸和木质素的生物合成。

木质素是苯丙氨酸衍生的聚合物，其充当植物血管组织中细胞壁的主要成分。芳香族氨基酸Phe的生物合成为许多次级代谢产物（包括木质素和类黄酮）提供了前体。在这里，我们发现MYB转录因子MYB20，MYB42，MYB43和MYB85是在拟南芥（Arabidopsis thaliana）次生壁形成过程中直接激活木质素生物合成基因和Phe生物合成基因的转录调节因子。MYB20，MYB42，MYB43和MYB85的破坏导致生长发育缺陷和木质素生物合成的大量减少。此外，我们的数据表明，这些MYB蛋白直接激活了转录抑制因子，后者特异性抑制类黄酮的生物合成，而后者与木质素的生物合成竞争Phe前体。

更新日期：2020-03-03

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