Previous studies have reported that acrolein, may exert harmful effects on the brain. However, information regarding the neuroprotective properties of guarana against acrolein is not available. Due to the lack of research, we initiated the current study to investigate the effects of guarana extracts on acrolein-induced toxicity in the liver and the central nervous system of Wistar Rats. Twelve groups of 60 days old Wistar rats treated with guarana extracts (150, 250, and 350 mg/kg/day) for 8 weeks, were challenged with acrolein (2.5 mg/kg/day). Several parameters associated with oxidative damage to the brain and hepatic function, as well as behavior were evaluated. All tested concentrations of guarana extracts exerted protective effects against acrolein induced damage. No hepatic and oxidative damages or behavioral changes were observed in guarana control groups. To the best of our knowledge, this is the first study of its kind and therefore a milestone in this field.

先前的研究报道，丙烯醛可能对大脑产生有害影响。但是，没有关于瓜拉那对丙烯醛的神经保护特性的信息。由于缺乏研究，我们启动了当前研究，以研究瓜拉纳提取物对丙烯醛对Wistar大鼠肝脏和中枢神经系统的毒性影响。用丙烯醛（2.5 mg / kg /天）攻击十二个用瓜拉那提取物（150、250和350 mg / kg /天）治疗60天的Wistar大鼠8周。评估了与脑部和肝功能的氧化损伤相关的几个参数以及行为。所有测试浓度的瓜拉纳提取物均对丙烯醛诱导的损伤具有保护作用。在瓜拉纳对照组中未观察到肝和氧化损伤或行为改变。据我们所知，这是同类研究中的第一次，因此是该领域的一个里程碑。