Despite of the extensive application of photodynamic therapy (PDT)nowadays, several restrictions have emerged such as hydrophobility, undesired phototoxicity and low selectivity of photosensitizer as well as the hypoxic tumor microenvironment. To address these challenges, a multifunctional mesoporous carbon‑manganese nanocomposite (MC-MnO2) is developed to load Chlorin e6 (Ce6) with a high loading capacity. The MC-MnO2 can prevent Ce6 from being activated by the sunlight to reduce unintentional phototoxicity significantly and realize the hypoxia relief via reacting with the H2O2 overexpressed in tumor tissue, meanwhile, the reduced product Mn2+ ion could act as a T1/T2-weighted MRI contrast. Based on the broad absorption of MC-MnO2 within the range of NIR, the nanoparticle has the potential for serving as a photothermal agent and photoacoustic imaging (PAI) agent. The PEG and iRGD are further decorated on MC-MnO2 (iPMC-MnO2) to improve the biocompatibility, targeting and penetration of the nanoparticle. Taking full advantage of the good photothermal effect of iPMC-MnO2, the photothermal therapy (PTT) and enhanced PDT are subtly integrated into one system, developing an intelligent multimodal diagnostic and therapeutic nanoplatform and realizing our "one nanoparticle fits all" dream.

中文翻译：

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介孔碳锰纳米复合材料，用于多次成像引导的氧升高协同治疗。

尽管如今光动力疗法（PDT）的广泛应用，但出现了一些限制，例如疏水性，不良的光毒性和光敏剂的选择性低以及低氧性肿瘤微环境。为了应对这些挑战，开发了一种多功能的介孔碳锰纳米复合材料（MC-MnO2），以高负载量负载氯霉素e6（Ce6）。MC-MnO2可以防止Ce6被阳光激活，从而显着降低意外的光毒性，并通过与肿瘤组织中过表达的H2O2反应来实现缺氧缓解，同时，还原产物Mn2 +离子可以作为T1 / T2加权MRI对比。基于MC-MnO2在NIR范围内的广泛吸收，该纳米颗粒具有用作光热剂和光声成像（PAI）剂的潜力。PEG和iRGD在MC-MnO2（iPMC-MnO2）上进一步修饰，以改善纳米颗粒的生物相容性，靶向性和渗透性。充分利用iPMC-MnO2的良好光热效应，将光热疗法（PTT）和增强的PDT巧妙地集成到一个系统中，开发出一种智能的多模式诊断和治疗纳米平台，实现了我们的“一个纳米粒子适合所有人”的梦想。