Hypoxia-responsive nanoparticle based drug delivery systems in cancer therapy: An up-to-date review.,Journal of Controlled Release

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Hypoxia-responsive nanoparticle based drug delivery systems in cancer therapy: An up-to-date review.
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2019-12-24 , DOI: 10.1016/j.jconrel.2019.12.041
Rashmi Kumari ₁ , Dhanya Sunil ₁ , Raghumani S Ningthoujam ₂

Affiliation

Hypoxia is a salient feature observed in most solid malignancies that holds a pivotal role in angiogenesis, metastasis and resistance to conventional cancer therapeutic approaches, and thus enables cancer progression. However, the typical characteristics of hypoxic cells such as low oxygen levels and highly bio-reductive environment can offer stimuli-responsive drug release to aid in tumor-specific chemo, radio, photodyanamic and sonodynamic therapies. This approach based on targeting the poorly oxygenated tumor habitats offers the prospective to overcome the difficulties that arises due to heterogenic nature of tumor and could be possibly used in the design of diagnostic as well as therapeutic nanocarriers for targeting various types of solid cancers. Consequently, hypoxia triggered nanoparticle based drug delivery systems is a rapidly progressing research area in developing effective strategies to combat drug-resistance in solid tumors. The present review presents the recent advances in the development of hypoxia-responsive nanovehicles for drug delivery to heterogeneous tumors. The initial sections of the article provides insights into the development of hypoxia in growing cancer and its role in disease progression. The current limitations and the future prospective of hypoxia-stimulated nanomachines for cancer treatment are also discussed.

中文翻译：

基于缺氧反应的纳米颗粒药物递送系统在癌症治疗中的应用：最新评论。

缺氧是在大多数实体恶性肿瘤中观察到的一个显着特征，它在血管生成，转移和对常规癌症治疗方法的抗性中起关键作用，从而使癌症得以进展。然而，低氧细胞的典型特征，例如低氧水平和高度生物还原性环境，可以提供刺激反应性药物释放，以辅助肿瘤特异性化学疗法，放射疗法，光动力疗法和声动力学疗法。这种基于靶向氧合不良的肿瘤生境的方法为克服由于肿瘤的异质性而引起的困难提供了前途，并可能用于设计针对各种类型的实体癌的诊断和治疗性纳米载体。所以，缺氧触发的基于纳米颗粒的药物递送系统是快速发展的研究领域，其发展了有效的策略来对抗实体瘤中的耐药性。本综述介绍了低氧反应性纳米车辆用于药物输送到异质性肿瘤的最新进展。本文的初始部分提供了对缺氧在生长中的癌症的发展及其在疾病进展中的作用的见解。还讨论了缺氧刺激的纳米机在癌症治疗中的当前局限性和未来的前景。本文的初始部分提供了对缺氧在生长中的癌症的发展及其在疾病进展中的作用的见解。还讨论了缺氧刺激的纳米机在癌症治疗中的当前局限性和未来的前景。本文的初始部分提供了对缺氧在生长中的癌症的发展及其在疾病进展中的作用的见解。还讨论了缺氧刺激的纳米机在癌症治疗中的当前局限性和未来的前景。

更新日期：2019-12-25

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