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Towards Preparative Chemoenzymatic Oxidative Decarboxylation of Glutamic Acid
ChemCatChem ( IF 3.8 ) Pub Date : 2020-01-22 , DOI: 10.1002/cctc.201902194 Xiaomin Xu 1 , Andrada But 1 , Ron Wever 2 , Frank Hollmann 1
ChemCatChem ( IF 3.8 ) Pub Date : 2020-01-22 , DOI: 10.1002/cctc.201902194 Xiaomin Xu 1 , Andrada But 1 , Ron Wever 2 , Frank Hollmann 1
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The chemoenzymatic oxidative decarboxylation of glutamic acid to the corresponding nitrile using the vanadium chloroperoxidase from Curvularia inaequalis (CiVCPO) as HOBr generation catalysts has been investigated. Product inhibition was identified as major limitation. Nevertheless, 1630000 turnovers and kcat of 75 s−1 were achieved using 100 mM glutamate. The semi‐preparative enzymatic oxidative decarboxylation of glutamate was also demonstrated.
中文翻译：
谷氨酸的制备型化学酶氧化脱羧
已经研究了使用来自不等弯孢的钒氯过氧化物酶（Ci VCPO）作为HOBr生成催化剂将谷氨酸化学酶氧化脱羧为相应的腈。产物抑制被确定为主要限制。尽管如此，1630000次失误并且k猫第75号第-1使用100mM的谷氨酸得以实现。还证明了谷氨酸的半制备酶氧化脱羧。
更新日期：2020-01-22
中文翻译：
谷氨酸的制备型化学酶氧化脱羧
已经研究了使用来自不等弯孢的钒氯过氧化物酶（Ci VCPO）作为HOBr生成催化剂将谷氨酸化学酶氧化脱羧为相应的腈。产物抑制被确定为主要限制。尽管如此，1630000次失误并且k猫第75号第-1使用100mM的谷氨酸得以实现。还证明了谷氨酸的半制备酶氧化脱羧。
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