Galactoxyloglucan Endowed Biogenic Nanoimmunobiotics Arrests Microbial Growth and Elicits Antitumor Immunity,ACS Applied Bio Materials

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Galactoxyloglucan Endowed Biogenic Nanoimmunobiotics Arrests Microbial Growth and Elicits Antitumor Immunity
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-01-10 , DOI: 10.1021/acsabm.9b00834
Manu M Joseph ₁ , Neethu Hari ₂ , Raveendran K Pillai ₃ , Ananthakrishnan J Nair ₂ , Sreelekha Therakathinal T ₁

Affiliation

A straightforward investigation with a surfactant-free green method mediated orchestration of a nanocomposite, where immunotherapy was fused with antimicrobial ability in a biogenic amalgamation, resulted in a nanoimmunobiotics (NIB). Consequently, a galactoxyloglucan (PST001) isolated from Tamarindus indica seed kernel was utilized in a sustainable approach to endow copper nanoparticles ([email protected]) with high stability and broad pH tolerance. The biocompatible nature of the [email protected] was demonstrated by toxicity studies on BALB/c mice. The nanoparticles exhibited immunomodulatory features by stimulating both humoral and cell-mediated immunity. As remarkable aftermath, we observed promising wound healing capacity on normal human keratinocytes along with the excellent antibacterial and antifungal activity by the NIB. The unique potential of [email protected] as a chemopreventive agent by eliciting antitumor immunity was illustrated on syngeneic murine tumor models. The outstanding capacity to reduce tumor burden with a significant increase in lifespan and a peculiar cytokine activation pattern could materialize these nanoparticles as an adjuvant for cancer management. The intrinsically bioeliminable, well-tolerated, and systemically available NIB promises to enter clinical testing as an antimicrobial-immunotherapy agent. Appreciable biodistribution pattern, along with the cost-effective fabrication strategies for scale-up, presents a futuristic biomedical scenario for fast promoting the translational potential of our NIB to combat antibiotic resistance and neoplasia effectively.

中文翻译：

半乳木葡聚糖赋予生物源纳米免疫生菌阻止微生物生长并引发抗肿瘤免疫

使用无表面活性剂的绿色方法介导的纳米复合材料编排的直接研究，其中免疫疗法与生物源融合中的抗菌能力相结合，产生了纳米免疫生物 (NIB)。因此，从罗望子 ( Tamarindus indica ) 中分离出的半乳木葡聚糖 (PST001)种子仁以可持续的方式被用于赋予铜纳米粒子（[电子邮件保护]）高稳定性和广泛的 pH 耐受性。对 BALB/c 小鼠的毒性研究证明了 [电子邮件保护] 的生物相容性。纳米粒子通过刺激体液和细胞介导的免疫表现出免疫调节特征。作为显着的后果，我们观察到正常人角质形成细胞具有良好的伤口愈合能力以及 NIB 出色的抗菌和抗真菌活性。[email protected] 通过引发抗肿瘤免疫作为化学预防剂的独特潜力在同基因小鼠肿瘤模型中得到了说明。通过显着延长寿命和特殊的细胞因子激活模式来减轻肿瘤负担的出色能力可以使这些纳米颗粒成为癌症治疗的佐剂。本质上可生物消除、耐受性良好且系统可用的 NIB 有望作为抗菌免疫治疗剂进入临床试验。可观的生物分布模式，以及具有成本效益的放大制造策略，为快速提升我们的 NIB 的转化潜力以有效对抗抗生素耐药性和肿瘤形成提供了一种未来的生物医学方案。

更新日期：2020-01-10

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