Unraveling the large number of various signals in the brain under the influence of physical and chemical cues that govern the formation of individual neurons, axons, dendrites, and their functional synapses during the development of neural network is a challenging task. To understand this task, microfluidic devices equipped with microchannels for reconstitution of cell/tissue-culture environments have been studied. Microfluidic devices are emerging as powerful tools in neurobiology, since they are capable of controlling and manipulating the microenvironment of the brain in a precise manner. They can enhance the physiological relevance of three-dimensional (3D) cell culture by allowing spatial control over fluids in micrometer-sized channels. Recent technological advancement in designing microfluidic platforms for studying neural communication, disease progression, and detection of neurotransmitters enhance our fundamental knowledge and understanding. However, more such advanced and innovative interventions are required. This Viewpoint focuses on highlighting a few of them with future scope of further advancement in this field.

中文翻译：

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具有神经有机体的三维微流控平台：解散突触的模型系统。

在控制神经网络发展过程中控制单个神经元，轴突，树突及其功能突触形成的物理和化学线索的影响下，揭示大脑中大量的各种信号是一项艰巨的任务。为了理解该任务，已经研究了配备有用于重建细胞/组织培养环境的微通道的微流体装置。微流体设备正在成为神经生物学中的强大工具，因为它们能够以精确的方式控制和操纵大脑的微环境。通过允许对微米级通道中的流体进行空间控制，它们可以增强三维（3D）细胞培养的生理相关性。在设计用于研究神经沟通的微流体平台方面的最新技术进步，疾病的进展以及神经递质的检测增强了我们的基本知识和理解。但是，需要更多这样的先进和创新干预措施。本观点着重于突出其中一些，并指出了该领域未来进一步发展的范围。