Hepatocellular carcinoma (HCC) is a common type of liver cancer that can be diagnosed by magnetic resonance imaging (MRI). If diagnosing HCC by basic MRI is difficult, then doctors use T₁-weighted or T₂-weighted imaging with a contrast agent that has long-term retention in the liver, such as Fe₃O₄ or FePt, to aid in MRI diagnosis. One challenging goal of cancer prevention is developing a method that can further treat or inhibit HCC cells at the time of diagnosis. Functionalized porous kaolinite can serve not only as a drug delivery system for treating cancer cells but also as a scaffold to carry FePt nanoparticles (FePt NPs) and drugs such as doxorubicin (Dox). FePt NPs combined with kaolinite modified with cetyltrimethylammonium bromide (CTAB) can form [email protected] nanocomposites. Multifunctional [email protected] can serve as a magnetic fluid hyperthermia (MFH) agent that can also be used to simultaneously visualize and treat HCC cancer cells. After being loaded with the chemotherapeutic drug Dox, [email protected] can provide both MFH treatment and chemotherapy. From the systematic analysis results, we demonstrated that this functionalized [email protected] nanocomposite can be successfully used as a platform to integrate MRI, magnetically guided targeting, and therapeutic treatment into a multifunctional drug delivery system.

中文翻译：

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磁导治疗学：使用像三明治的高岭石基铁/铂纳米粒子优化磁共振成像，用于磁流体热疗和化学疗法

肝细胞癌（HCC）是常见的肝癌类型，可以通过磁共振成像（MRI）进行诊断。如果难以通过基本MRI诊断HCC，则医生应使用T ₁加权或T ₂加权成像以及在肝脏中长期保留的造影剂（例如Fe ₃ O _4）或FePt，以帮助MRI诊断。癌症预防的一个具有挑战性的目标是开发一种在诊断时可以进一步治疗或抑制HCC细胞的方法。功能化的多孔高岭石不仅可以用作治疗癌细胞的药物输送系统，而且还可以用作携带FePt纳米颗粒（FePt NPs）和诸如阿霉素（Dox）的药物的支架。FePt NP与十六烷基三甲基溴化铵（CTAB）改性的高岭石结合可以形成[电子邮件保护的]纳米复合材料。多功能[受电子邮件保护]可用作磁流体热疗（MFH）剂，也可用于同时可视化和治疗HCC癌细胞。在装载了化疗药物Dox之后，[电子邮件保护]可以提供MFH治疗和化学疗法。从系统分析结果来看，