Pore Confinement-Enhanced Electrochemiluminescence on SnO2 Nanocrystal Xerogel with NO3- As Co-Reactant and Its Application in Facile and Sensitive Bioanalysis.,Analytical Chemistry

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Pore Confinement-Enhanced Electrochemiluminescence on SnO2 Nanocrystal Xerogel with NO3- As Co-Reactant and Its Application in Facile and Sensitive Bioanalysis.
Analytical Chemistry ( IF 6.7 ) Pub Date : 2020-01-10 , DOI: 10.1021/acs.analchem.9b05367
Yan-Mei Lei ₁ , Ying Zhuo ₁ , Mu-Lin Guo ₁ , Ya-Qin Chai ₁ , Ruo Yuan ₁

Affiliation

Herein, 10-fold electrochemiluminescence (ECL) enhancement from a porous SnO2 nanocrystal (SnO2 NC) xerogel (vs discrete SnO2 NCs) was first observed with NO3- as a novel coreactant. This new booster phenomenon caused by pore characteristic was defined as "pore confinement-induced ECL enhancement", which originated from two possible reasons: First, the SnO2 NC xerogel with hierarchically porous structure could not only localize massive luminophore near the electrode surface, more importantly, but could accelerate the electrochemical and chemiluminescence reaction efficiency because the pore channels of xerogel could promote the mass transport and electron transfer in the confined spaces. Second, the NO3- could be in situ reduced easily to the active nitrogen species by means of the pore confinement effect, which could be served as a new coreactant for nanocrystal-based ECL amplification with the excellent stability and good biocompatibility. As a proof of concept, a facile and sensitive sensing platform for SO32- detection has been successfully constructed upon effectively quenching of SO32- toward the SnO2 NC xerogel/NO3- ECL system. The key feature about this work presented a grand avenue to achieve the strong ECL signal, especially from weak emitters, which gave a fresh impetus to the construction of new-generation of surface-confined ECL platform with potential applications in ECL imaging and sensing.

中文翻译：

以NO3-为共反应剂的SnO2纳米晶干凝胶上的孔封闭增强电化学发光及其在灵敏和灵敏的生物分析中的应用。

在本文中，首先观察到了以NO3-作为新型共反应剂的多孔SnO2纳米晶体（SnO2 NC）干凝胶（相对于离散SnO2 NCs）的10倍电化学发光（ECL）增强。这种由孔隙特征引起的新的助推现象被定义为“孔隙限制引起的ECL增强”，其起因有两个可能的原因：首先，具有分层多孔结构的SnO2 NC干凝胶不仅可以将大量的发光体定位在电极表面附近，更重要的是，但由于干凝胶的孔道可以促进密闭空间内的质量传输和电子转移，因此可以加快电化学和化学发光反应的效率。其次，借助孔隙限制效应，NO3-可以很容易地就地还原为活性氮。具有良好的稳定性和良好的生物相容性，可作为基于纳米晶体的ECL扩增的新型共反应剂。作为概念的证明，在将SO32-有效地淬灭至SnO2 NC干凝胶/ NO3-ECL系统后，已经成功构建了用于SO32检测的简便而灵敏的传感平台。这项工作的关键特征为获得强ECL信号（特别是来自弱发射器的信号）提供了广阔的途径，这为新一代表面受限ECL平台的构建提供了新的动力，该平台在ECL成像和传感方面具有潜在的应用前景。通过有效地朝SnO2 NC干凝胶/ NO3- ECL系统淬灭SO32-，已经成功构建了一个简便，灵敏的SO32-检测平台。这项工作的关键特征为获得强ECL信号（特别是来自弱发射器的信号）提供了广阔的途径，这为新一代表面受限ECL平台的构建提供了新的动力，该平台在ECL成像和传感方面具有潜在的应用前景。通过有效地朝SnO2 NC干凝胶/ NO3- ECL系统淬灭SO32-，已经成功构建了一个简便，灵敏的SO32-检测平台。这项工作的关键特征为获得强ECL信号（特别是来自弱发射器的信号）提供了广阔的途径，这为新一代表面受限ECL平台的构建提供了新的动力，该平台在ECL成像和传感方面具有潜在的应用前景。

更新日期：2020-01-10

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