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Disulfide bridge as a linker in nucleic acids' bioconjugation. Part II: A summary of practical applications.
Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2019-12-23 , DOI: 10.1016/j.bioorg.2019.103518
Anna R Stasińska 1 , Piotr Putaj 2 , Marcin K Chmielewski 1
Affiliation  

Disulfide conjugation invariably remains a key tool in research on nucleic acids. This versatile and cost-effective method plays a crucial role in structural studies of DNA and RNA as well as their interactions with other macromolecules in a variety of biological systems. In this article we review applications of disulfide-bridged conjugates of oligonucleotides with other (bio)molecules such as peptides, proteins etc. and present key findings obtained with their help.

中文翻译:

二硫键作为核酸生物共轭中的连接子。第二部分:实际应用概述。

二硫键结合始终是核酸研究中的关键工具。这种通用且经济高效的方法在DNA和RNA的结构研究以及它们与各种生物系统中其他大分子的相互作用中起着至关重要的作用。在本文中,我们回顾了寡核苷酸与其他(生物)分子(如肽,蛋白质等)的二硫键桥接共轭物的应用,并介绍了在其帮助下获得的重要发现。
更新日期:2019-12-23
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