Piezo channel is one of the mechanosensitive channels that senses pressure and shearing stress. Previous reports show that Piezo channel is expressed in many tissues such as skin and lung and they have many important roles. In addition, the mRNA of Piezo has been detected in astrocytes in the optic nerve head of mice. However, it is not yet clear where Piezo channel localize in eye and what kind of effects it have. Thus, the purpose of this study was to determine the expression sites of Piezo channel in mouse eyes and effect of Piezo channel on retinal ganglion cells. Immunostaining analysis showed that the Piezo 1/2 were expressed in the cornea, trabecular meshwork of the anterior ocular segment, lens epithelial cells, and on the retinal ganglion cell layer. The expression of retinal Piezo 2 was increased in retinal disorder model mouse caused by high IOP. Piezo 1 agonist Yoda 1 suppressed neurite outgrowth in retinal ganglion cells. On the other hand, Piezo antagonist GsMTx4 promoted neurite outgrowth in retinal ganglion cells. These findings indicate that Piezo channel may contribute to diseases relating the IOP such as glaucoma.

中文翻译：

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压电通道在视网膜神经节细胞损伤中起作用。

压电通道是感应压力和剪切应力的机械敏感通道之一。以前的报道表明，压电通道在皮肤和肺等许多组织中表达，它们具有许多重要作用。另外，已经在小鼠的视神经头的星形胶质细胞中检测到Piezo的mRNA。但是，尚不清楚压电通道在眼中的位置以及它具有什么样的作用。因此，本研究的目的是确定小鼠眼中压电通道的表达位点以及压电通道对视网膜神经节细胞的影响。免疫染色分析表明，Piezo 1/2在角膜，前眼小梁的小梁网，晶状体上皮细胞和视网膜神经节细胞层中表达。高眼压引起的视网膜疾病模型小鼠视网膜Piezo 2的表达增加。压电1激动剂Yoda 1抑制了视网膜神经节细胞中的神经突生长。另一方面，压电拮抗剂GsMTx4促进了视网膜神经节细胞中的神经突生长。这些发现表明，压电通道可能导致与眼压有关的疾病，例如青光眼。