Insulin-derived amyloidosis without a palpable mass at the insulin injection site: A report of two cases.,Journal of Diabetes Investigation

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Insulin-derived amyloidosis without a palpable mass at the insulin injection site: A report of two cases.
Journal of Diabetes Investigation ( IF 3.1 ) Pub Date : 2020-01-19 , DOI: 10.1111/jdi.13199
Terumasa Nagase ₁ , Keiichi Iwaya ₂ , Koichiro Kogure ₁ , Tamotsu Zako ₃ , Yohei Misumi ₄ , Minoru Kikuchi ₅ , Koichi Matsumoto ₆ , Masayuki Noritake ₁ , Yasuhiro Kawachi ₇ , Masaki Kobayashi ₈ , Yukio Ando ₄ , Yoshiya Katsura ₁

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To date, almost all case reports of insulin‐derived amyloidosis described the presence of a subcutaneous mass that was observable on physical examination. This report presents two cases of insulin‐derived amyloidosis without palpable masses at insulin injection sites. In both cases, blood glucose concentrations improved, and the insulin dose could be reduced by an average of 45% after changing the insulin injection sites. The insulin absorption at the site was reduced to at most 40% of that at a normal site in one case. Magnetic resonance imaging and ultrasonography were useful to screen and differentiate insulin‐derived amyloidosis without a palpable mass. This report showed that insulin‐derived amyloidosis without a palpable mass can be present at the insulin injection site, and has similar clinical effects to insulin‐derived amyloidosis with palpable masses.

中文翻译：

胰岛素源性淀粉样变性，胰岛素注射部位无明显肿块：两例报告。

迄今为止，几乎所有胰岛素源性淀粉样变性病例报告都描述了体检时可观察到的皮下肿块的存在。本报告介绍了两例胰岛素源性淀粉样变性病例，在胰岛素注射部位未触及肿块。在这两种情况下，改变胰岛素注射部位后，血糖浓度均有所改善，胰岛素剂量平均可减少 45%。在一例中，该部位的胰岛素吸收最多减少至正常部位的 40%。磁共振成像和超声检查可用于筛查和鉴别无明显肿块的胰岛素源性淀粉样变性。该报告表明，无可触及肿块的胰岛素源性淀粉样变性可存在于胰岛素注射部位，并且与可触及肿块的胰岛素源性淀粉样变性具有相似的临床效果。

更新日期：2020-01-19

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