Abstract Gellan microgels incorporated with jabuticaba extract were produced by external gelation of monodisperse water-in-oil (W/O) emulsions. This extract, rich in anthocyanins, has shown antioxidant effect and benefits associated to intestinal issues. The W/O emulsions were produced using a three-dimensional microfluidic device operated in an intermittent dripping regime flow. Microgels were obtained from external gelation of emulsions by calcium ions present in the continuous phase. Our results showed how to produce and control the microgel diameter and polydispersity by varying the flow rate of continuous and dispersed phases. Diameter of microgels ranged from 185 μm to 342 μm, and coefficient of variation values varied between 1.6 and 8.6%. The low stability of microgels loaded with jabuticaba extract was mainly associated with both the low gellan concentration and the osmotic pressure difference during storage. In spite of this, the microfluidic route proposed can potentially be used to incorporate and protect anthocyanins extracts and might be extended for other hydrophilic molecules.

中文翻译：

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开发一种微流体途径，用于形成包含 jabuticaba（Myrciaria cauliflora）提取物的结冷胶微凝胶

摘要 通过单分散油包水 (W/O) 乳剂的外部凝胶化，可以生产出掺有木犀草提取物的结冷胶微凝胶。这种富含花青素的提取物已显示出抗氧化作用和与肠道问题相关的益处。W/O 乳液是使用在间歇滴流状态下运行的三维微流体装置生产的。微凝胶是通过连续相中存在的钙离子从乳液的外部凝胶化中获得的。我们的结果显示了如何通过改变连续相和分散相的流速来生产和控制微凝胶直径和多分散性。微凝胶的直径范围从 185 μm 到 342 μm，变异系数值在 1.6% 到 8.6% 之间变化。载有jabuticaba 提取物的微凝胶的低稳定性主要与低结冷胶浓度和储存期间的渗透压差有关。尽管如此，所提出的微流体途径有可能用于合并和保护花青素提取物，并可能扩展到其他亲水性分子。