Phylogenetic studies on foot-and-mouth disease viruses (FMDVs) circulating in the West Eurasian region have largely focused on the genomic sequences encoding the structural proteins that determine the serotype. The present study has compared near-complete genome sequences of FMDVs representative of the viruses that circulate in this region. The near-complete genome sequences (ca. 7,600 nt) were generated from multiple overlapping RT-PCR products. These amplicons were from FMDVs belonging to serotypes O, A and Asia-1, including members of the O-PanAsia-II and the A-Iran05 lineages, and of Group-II and Group-VII (Sindh-08) within serotype Asia-1, which are currently predominant and widespread in West Eurasia. These new sequences were analysed together with other sequences obtained from GenBank. Comparison of different regions of the FMDVs genomes revealed evidence for multiple, inter-serotypic, recombination events between FMDVs belonging to the serotypes O, A and Asia-1. It is concluded from the present study that dramatic changes in virus sequences can occur in the field through recombination between different FMDV genomes. These analyses provide information about the ancestry of the serotype O, A and Asia-1 FMDVs that are currently circulating within the West Eurasian region.

中文翻译：

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在西欧亚大陆传播的口蹄疫病毒内发生多种重组事件的证据。

对在西欧亚地区传播的口蹄疫病毒（FMDV）的系统发育研究，主要集中在编码决定血清型的结构蛋白的基​​因组序列上。本研究比较了代表在该区域中传播的病毒的FMDV的近乎完整的基因组序列。从多个重叠的RT-PCR产物中产生了近乎完整的基因组序列（约7,600 nt）。这些扩增子来自属于O，A和Asia-1血清型的FMDV，包括O-PanAsia-II和A-Iran05血统的成员，以及属于Asia-血清型的II-组和VII-组（Sindh-08）。 1，目前在西欧亚大陆占主导地位并广泛分布。这些新序列与从GenBank获得的其他序列一起进行了分析。FMDVs基因组不同区域的比较揭示了属于血清型O，A和Asia-1的FMDV之间多重血清型重组事件的证据。从本研究得出的结论是，通过不同FMDV基因组之间的重组，病毒序列会在野外发生巨大变化。这些分析提供了有关西欧亚地区目前正在流行的O型，A型和Asia-1型FMDV血统的信息。