BACKGROUND This study explored the association between inactive time and measures of adiposity, clinical parameters, obesity, type 2 diabetes and metabolic syndrome components. It further examined the impact of reallocating inactive time to time in bed, light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on cardio-metabolic risk factors, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. METHODS This is a cross-sectional analysis of baseline data from 2189 Caucasian men and women (age 55-75 years, BMI 27-40 Kg/m2) from the PREDIMED-Plus study (http://www.predimedplus.com/). All participants had ≥3 components of the metabolic syndrome. Inactive time, physical activity and time in bed were objectively determined using triaxial accelerometers GENEActiv during 7 days (ActivInsights Ltd., Kimbolton, United Kingdom). Multiple adjusted linear and logistic regression models were used. Isotemporal substitution regression modelling was performed to assess the relationship of replacing the amount of time spent in one activity for another, on each outcome, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. RESULTS Inactive time was associated with indicators of obesity and the metabolic syndrome. Reallocating 30 min per day of inactive time to 30 min per day of time in bed was associated with lower BMI, waist circumference and glycated hemoglobin (HbA1c) (all p-values < 0.05). Reallocating 30 min per day of inactive time with 30 min per day of LPA or MVPA was associated with lower BMI, waist circumference, total fat, visceral adipose tissue, HbA1c, glucose, triglycerides, and higher body muscle mass and HDL cholesterol (all p-values < 0.05). CONCLUSIONS Inactive time was associated with a poor cardio-metabolic profile. Isotemporal substitution of inactive time with MVPA and LPA or time in bed could have beneficial impact on cardio-metabolic health. TRIAL REGISTRATION The trial was registered at the International Standard Randomized Controlled Trial (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.

中文翻译：

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用体力活动和卧床时间替代非活动时间的等时性：PREDIMED-Plus 研究中与心脏代谢健康的横断面关联。

背景本研究探讨了不活动时间与肥胖、临床参数、肥胖、2 型糖尿病和代谢综合征组成部分的测量之间的关联。它进一步研究了重新分配卧床不活动时间、轻度体力活动 (LPA) 或中度至剧烈体力活动 (MVPA) 对心脏代谢危险因素的影响，包括肥胖和身体成分、生化参数和血液的测量老年人的压力。方法 这是对来自 PREDIMED-Plus 研究 (http://www.predimedplus.com/) 的 2189 名白人男性和女性（年龄 55-75 岁，BMI 27-40 Kg/m2）的基线数据进行横断面分析。 。所有参与者均患有≥3种代谢综合征。使用三轴加速度计 GENEActiv（ActivInsights Ltd.，Kimbolton，英国）客观确定 7 天内的不活动时间、体力活动和床上时间。使用多重调整线性和逻辑回归模型。采用等时替代回归模型来评估将一项活动所花费的时间替换为另一项活动所花费的时间与每个结果的关系，包括老年人的肥胖和身体成分、生化参数和血压的测量。结果 不活动时间与肥胖和代谢综合征指标相关。将每天 30 分钟的不活动时间重新分配为每天 30 分钟的卧床时间与较低的 BMI、腰围和糖化血红蛋白 (HbA1c) 相关（所有 p 值 < 0.05）。每天重新分配 30 分钟的不活动时间，每天 30 分钟的 LPA 或 MVPA 与较低的 BMI、腰围、总脂肪、内脏脂肪组织、HbA1c、葡萄糖、甘油三酯以及较高的身体肌肉质量和 HDL 胆固醇相关（所有 p -值 < 0.05)。结论 不活动时间与较差的心脏代谢状况相关。用 MVPA 和 LPA 或卧床时间替代不活动时间的等时可能对心脏代谢健康产生有益影响。试验注册该试验在国际标准随机对照试验（ISRCTN：http://www.isrctn.com/ISRCTN89898870）上注册，注册号为89898870，注册日期为2014年7月24日，为追溯注册。