BACKGROUND Relative to their application with adults there is currently little information about the application of preference-based health-related quality of life (HRQL) instruments among populations of young people. The Child Health Utility 9D (CHU9D) is a paediatric-specific generic preference-based HRQL instrument, recently translated and linguistically validated into Danish (CHU9D-DK). The purpose of this study was to investigate the construct validity of the CHU9D-DK in a sample of Danish high school students. METHODS All students attending a Danish High School were invited to participate in a web-based survey in January 2018 (N = 272). The survey included the CHU9D-DK, the young adult version of the Pediatric Quality of Life Inventory™ 4.0 Generic Core Scales (PedsQL), self-reported health status, presence/absence of disability/chronic diseases, life satisfaction, and socio-economic questions. CHU9D-DK utility scores were generated by employing the two scoring algorithms developed from adults in the UK and adolescents in Australia, respectively. Internal consistency, reliability and construct validity of the CHU9D-DK instrument were investigated. RESULTS Two hundred and twenty-eight (84%) students consented to participate and completed the survey. The mean ± (standard deviation) values of the CHU9D-DK utilities were 0.84 (0.11) when the UK adult algorithm was applied and 0.70 (0.22), when the Australian adolescent algorithm was applied. The mean PedsQL score was 82.32 (13.14). The CHU9D-DK showed good internal consistency reliability (Cronbach's alpha = 0.803). Higher levels of health status and life satisfaction were significantly associated with higher CHU9D-DK utility scores regardless of which scoring algorithm was applied (p-values < 0.001). Students living with a disability/chronic disease exhibited significantly lower utility scores relative to their healthy peers (p-values < 0.05). Higher socio-economic status (approximated by financial situation and frequency of family vacations) was also associated with higher utility scores (p-values < 0.005). CONCLUSION The CHU9D-DK demonstrated good psychometric performance overall and shows potential as a valid and reliable instrument for assessing the HRQL of Danish young people. TRIAL REGISTRATION ClinicalTrials.gov identifier: NCT03391999, Registered 15 October 2017.

中文翻译：

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Child Health Utility 9D-DK仪器的构造有效性。

背景技术相对于其与成年人的应用，目前关于在年轻人群中基于偏好的健康相关生活质量（HRQL）工具的应用的信息很少。儿童保健实用程序9D（CHU9D）是一种基于儿科的通用通用偏好HRQL仪器，最近已翻译并经过语言验证为丹麦语（CHU9D-DK）。这项研究的目的是调查在丹麦高中学生样本中CHU9D-DK的构建有效性。方法2018年1月，所有就读丹麦高中的学生均被邀请参加基于网络的调查（N = 272）。该调查包括CHU9D-DK，《儿童生活质量量表》 4.0通用核心量表（PedsQL）的年轻成人版本，自我报告的健康状况，有无残疾/慢性疾病，生活满意度和社会经济问题。CHU9D-DK实用分数是通过分别采用从英国成人和澳大利亚青少年开发的两种评分算法得出的。研究了CHU9D-DK仪器的内部一致性，可靠性和构建效度。结果228名（84％）学生同意参加并完成调查。当使用UK成人算法时，CHU9D-DK实用程序的平均值±（标准偏差）值为0.84（0.11），而当应用澳大利亚青少年算法时，则为0.70（0.22）。PedsQL的平均得分为82.32（13.14）。CHU9D-DK显示出良好的内部一致性可靠性（Cronbach's alpha = 0.803）。无论使用哪种评分算法，较高的健康状况和生活满意度与较高的CHU9D-DK实用分数均显着相关（p值<0.001）。与健康的同龄人相比，患有残疾/慢性病的学生的效用得分要低得多（p值<0.05）。较高的社会经济地位（由财务状况和家庭度假的频率近似）也与较高的效用得分相关（p值<0.005）。结论CHU9D-DK总体上表现出良好的心理测量性能，并显示出作为评估丹麦年轻人HRQL的有效和可靠工具的潜力。试验注册ClinicalTrials.gov标识符：NCT03391999，于2017年10月15日注册。