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Topical antimicrobial peptide formulations for wound healing: Current developments and future prospects.
Acta Biomaterialia ( IF 9.4 ) Pub Date : 2019-12-21 , DOI: 10.1016/j.actbio.2019.12.025 Raj Kumar Thapa 1 , Dzung B Diep 2 , Hanne Hjorth Tønnesen 1
Acta Biomaterialia ( IF 9.4 ) Pub Date : 2019-12-21 , DOI: 10.1016/j.actbio.2019.12.025 Raj Kumar Thapa 1 , Dzung B Diep 2 , Hanne Hjorth Tønnesen 1
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Antimicrobial peptides (AMPs) are the natural antibiotics recognized for their potent antibacterial and wound healing properties. Bare AMPs have limited activity following topical application attributable to their susceptibility to environment (hydrolysis, oxidation, photolysis), and wound (alkaline pH, proteolysis) related factors as well as minimal residence time. Therefore, the formulation of AMPs is essential to enhance stability, prolong delivery, and optimize effectiveness at the wound site. Different topical formulations of AMPs have been developed so far including nanoparticles, hydrogels, creams, ointments, and wafers to aid in controlling bacterial infection and enhance wound healing process in vivo. Herein, an overview is provided of the AMPs and current understanding of their formulations for topical wound healing applications along with suitable examples. Furthermore, future prospects for the development of effective combination AMP formulations are discussed. STATEMENT OF SIGNIFICANCE: Chronic wound infection and subsequent development of antibiotic resistance are serious clinical problems affecting millions of people worldwide. Antimicrobial peptides (AMPs) possess great potential in effectively killing the bacteria with minimal risk of resistance development. However, AMPs susceptibility to degradation following topical application limits their antimicrobial and wound healing effects. Therefore, development of an optimized topical formulation with high peptide stability and sustained AMP delivery is necessary to maximize the antimicrobial and wound healing effects. The present review provides an overview of the state-of-art in the field of topical AMP formulations for wound healing. Current developments in the field of topical AMP formulations are reviewed and future prospects for the development of effective combination AMP formulations are discussed.
中文翻译：
用于伤口愈合的局部抗菌肽制剂：当前的发展和未来的前景。
抗菌肽（AMPs）是公认的有效抗菌和伤口愈合特性的天然抗生素。裸露的AMPs在局部应用后活性有限，这归因于其对环境（水解，氧化，光解）和伤口（碱性pH，蛋白水解）相关因素的敏感性以及最短的停留时间。因此，AMPs的制剂对于增强稳定性，延长递送和优化伤口部位的有效性至关重要。迄今为止，已经开发了AMP的不同局部制剂，包括纳米颗粒，水凝胶，乳膏，软膏和糯米纸囊剂，以帮助控制细菌感染并增强体内伤口愈合过程。在此处，提供了AMP的概述以及对于局部伤口愈合应用的AMP配方的最新了解以及合适的示例。此外，讨论了开发有效组合AMP制剂的未来前景。意义声明：慢性伤口感染和随后的抗生素耐药性发展是严重的临床问题，影响着全球数百万人。抗菌肽（AMPs）具有有效杀灭细菌的巨大潜力，且耐药性发展的风险极小。但是，AMPs在局部应用后易于降解，限制了其抗菌和伤口愈合作用。所以，开发具有高肽稳定性和持续AMP递送的优化局部制剂对于最大化抗菌和伤口愈合效果是必不可少的。本综述概述了用于伤口愈合的局部AMP制剂领域的最新技术。综述了局部AMP制剂领域的最新发展，并讨论了开发有效组合AMP制剂的未来前景。
更新日期：2019-12-23
中文翻译：
用于伤口愈合的局部抗菌肽制剂：当前的发展和未来的前景。
抗菌肽（AMPs）是公认的有效抗菌和伤口愈合特性的天然抗生素。裸露的AMPs在局部应用后活性有限，这归因于其对环境（水解，氧化，光解）和伤口（碱性pH，蛋白水解）相关因素的敏感性以及最短的停留时间。因此，AMPs的制剂对于增强稳定性，延长递送和优化伤口部位的有效性至关重要。迄今为止，已经开发了AMP的不同局部制剂，包括纳米颗粒，水凝胶，乳膏，软膏和糯米纸囊剂，以帮助控制细菌感染并增强体内伤口愈合过程。在此处，提供了AMP的概述以及对于局部伤口愈合应用的AMP配方的最新了解以及合适的示例。此外，讨论了开发有效组合AMP制剂的未来前景。意义声明：慢性伤口感染和随后的抗生素耐药性发展是严重的临床问题，影响着全球数百万人。抗菌肽（AMPs）具有有效杀灭细菌的巨大潜力，且耐药性发展的风险极小。但是，AMPs在局部应用后易于降解，限制了其抗菌和伤口愈合作用。所以，开发具有高肽稳定性和持续AMP递送的优化局部制剂对于最大化抗菌和伤口愈合效果是必不可少的。本综述概述了用于伤口愈合的局部AMP制剂领域的最新技术。综述了局部AMP制剂领域的最新发展，并讨论了开发有效组合AMP制剂的未来前景。
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